Author

W. McKerrow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. Fenyö· 2 shared J. LaCava· 2 shared P. Mita· 2 shared X. Wang· 2 shared A. Solovyov· 1 shared A. W. Drong· 1 shared B. D. Greenbaum· 1 shared B. Sie· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

D. Fenyö

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Author profile →

4 papers

Recent·Most cited

Mechanism-guided quantification of LINE-1 reveals p53 regulation of both retrotransposition and transcription

A. Solovyov, J. M. Behr, D. Hoyos, E. M. Banks, A. W. Drong, J. Z. Zhong, E. Garcia-Rivera, W. McKerrow, C. Chu, D. M. Zaller, M. Fromer, B. D. Greenbaum

This study quantifies LINE-1 retrotransposition and expression in cancer, showing TP53 mutations enable retrotransposition by disinhibiting L1 expression and enabling reintegration.

bioRxiv · May 11, 2023 · PreprintCancer Biology

LINE-1 ORF1p RIP-seq reveals widespread association with p-body enriched mRNAs

E. M. Briggs, W. McKerrow, P. Mita, J. D. Boeke, S. K. Logan, D. Fenyö

The paper uses RIP-seq and L1EM analysis to show ORF1p binds non-LINE-1 mRNAs and p-body enriched RNAs in prostate cancer cells, correlating with LINE-1 RNA levels in TCGA tumors.

bioRxiv · Aug 20, 2020Cell Biology

LINE-1 expression in cancer correlates with DNA damage response, copy number variation, and cell cycle progression

W. McKerrow, X. Wang, P. Mita, S. Cao, M. Grivainis, L. Ding, J. LaCava, J. Boeke, D. Fenyö

bioRxiv · Jun 26, 2020 · PreprintCancer Biology

LINE-1 ORF2P EXPRESSION IS NEARLY IMPERCEPTIBLE IN HUMAN CANCERS

D. Ardeljan, X. Wang, M. Oghbaie, M. S. Taylor, D. Husband, V. Deshpande, J. P. Steranka, M. Gorbounov, W. R. Yang, B. Sie, H. B. Larman, H. Jiang, K. R. Molloy, I. Altukhov, Z. Li, , J. LaCava

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

bioRxiv · Aug 22, 2019Cancer Biology