PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates
Y.-f. Xu, J. Sun, X. Yu, X. Chen, M. Cui, Z. Yang, C.-h. Liu, X.-z. Yang, Y.-j. Wang, S. Zhang, C. Wang, Z.-y. Zhang, W.-d. Zhao, C.-h. Wang, Z.-l. Ji, , Y.-c. Song
This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.
bioRxiv · Sep 17, 2020Cell Biology