Author

Y.-J. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 2 Bioengineering· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell signaling & trafficking· 5 Organism:human· 5 Organism:mouse· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:protein folding & dynamics· 3

Frequent Co-Authors

T. Mu· 3 shared T.-W. Mu· 3 shared C. Wang· 2 shared H. Gao· 2 shared S.-X. Yu· 2 shared W. Liu· 2 shared X.-J. Di· 2 shared X.-W. Xiang· 2 shared

Activity by Year

2020-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiochemistry

T. Mu

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Sex differences in GLP-1 signaling across species

Thomas Roseberry, Irene Grossrubatscher, Tim Krausz, Y.-J. Wang, Michael W. Schwartz, David Tingley

The paper investigates sex differences in GLP-1 receptor agonist side effects using EMR data and in vivo assays, finding higher nausea rates in women and estrous cycle-related variations in mice.

bioRxiv · Mar 17, 2025 · PreprintSystems Biology

Pathogenicity Prediction of GABAA Receptor Missense Variants

Y.-J. Wang, G. H. Vu, T. Mu

The paper predicts the pathogenicity of GABAA receptor missense variants using AlphaMissense and Rhapsody, showing good correlation between tools and identifying most ClinVar pathogenic variants.

bioRxiv · Nov 14, 2023Biochemistry

Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants

Y.-J. Wang, H. Seibert, L. Y. Ahn, A. E. Schaffer, T.-W. Mu

This study identifies pharmacological chaperones that restore function to epilepsy-associated GABAA receptor variants by enhancing folding and reducing degradation.

bioRxiv · Apr 18, 2023 · PreprintCell Biology

Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants

P.-P. Zhang, T. M. Benske, J. C. Paton, A. W. Paton, T. Mu, Y.-J. Wang

This study shows that enhancing ER proteostasis with BIX rescues the function of epilepsy-linked NMDAR variants by improving their folding and trafficking.

bioRxiv · Apr 1, 2023Cell Biology

Vaccinia virus induces EMT-like transformation and RhoA-mediated mesenchymal migration

W. Liu, J.-Y. Lu, Y.-J. Wang, X.-x. Xu, Y.-C. Chen, S.-X. Yu, X.-W. Xiang, X.-Z. Chen, Y. Jiu, H. Gao, M. Sheng, Z.-J. Chen, X. Hu, D. Li, P. Maiuri, , Y.-J. Liu

This study shows vaccinia virus induces EMT-like changes and RhoA-mediated mesenchymal migration in epithelial cells, facilitating viral spread.

bioRxiv · Feb 4, 2023Cell Biology

Hsp47 Promotes Biogenesis of Multi-subunit Neuroreceptors in the Endoplasmic Reticulum

Y.-J. Wang, X.-J. Di, D.-Y. Han, R. Nashmi, B. J. Henderson, F. J. Moss, T.-W. Mu

This study shows Hsp47 enhances GABAA receptor surface expression by binding folded receptors and promoting their assembly and trafficking, with similar effects on other Cys-loop receptors.

bioRxiv · Oct 24, 2022Cell Biology

Microsecond pulse electrical stimulation modulates cell migration

X.-W. Xiang, H.-T. Liu, W. Liu, Z.-Y. Yan, Y.-L. Zeng, Y.-J. Wang, J. Liu, Y.-C. Chen, S.-X. Yu, C.-H. Zhu, X.-N. Tao, C. Wang, J.-T. Wu, Y. Du, X.-X. Xu, , Y.-J. Liu

This study introduces microsecond pulse electric field (sPEF) to enhance wound healing by promoting fibroblast migration and ECM alignment, validated in 2D and 3D models and a mouse wound healing assay.

bioRxiv · Oct 23, 2022Bioengineering

Quantitative interactome proteomics identifies proteostasis network for GABAA receptors

Y.-J. Wang, X.-J. Di, T. Mu

The paper identifies the proteostasis network of GABAA receptors using quantitative proteomics, revealing key proteins involved in their biogenesis and function.

bioRxiv · Mar 8, 2022Biochemistry

The Endoplasmic Reticulum Membrane Complex Promotes Proteostasis of GABAA Receptors

A. Whittsette, Y.-J. Wang, T.-W. Mu

This study shows that EMC3 and EMC6 subunits of the endoplasmic reticulum membrane complex interact with GABAA receptors and enhance their trafficking and function, suggesting potential therapeutic applications for neurological diseases.

bioRxiv · Mar 3, 2022Cell Biology

PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates

Y.-f. Xu, J. Sun, X. Yu, X. Chen, M. Cui, Z. Yang, C.-h. Liu, X.-z. Yang, Y.-j. Wang, S. Zhang, C. Wang, Z.-y. Zhang, W.-d. Zhao, C.-h. Wang, Z.-l. Ji, , Y.-c. Song

This study identifies how PTP-MEG2 regulates exocytosis by dephosphorylating specific sites on NSF, DYNAMIN2, and MUNC18-1, revealing distinct structural mechanisms for substrate recognition.

bioRxiv · Sep 17, 2020Cell Biology