Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin
N. Zhang, J. Wu, F. Hossain, H. Peng, H. Li, C. Gibson, M. Chen, H. Zhang, S. Gao, X. Zheng, Y. Wang, J. Zhu, J. J. Wang, I. Maze, Q. Zheng
This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.
bioRxiv · Mar 20, 2024Biochemistry