imaging

ALIGN: A modular framework for quantitative analysis of longitudinal development in Caenorhabditis elegans

ALIGN provides a modular framework for analyzing longitudinal development in C. elegans, enabling accurate segmentation, quality control, and motion correction across imaging conditions.

Disentangling visual and motor contributions to continuous psychophysics

This study disentangles visual and motor contributions to tracking performance in continuous psychophysics by analyzing cross-correlogram metrics under visual impairment and hand dominance conditions.

Evolution of Vesicle Shape Parameters Based on A Deep-Learning Based Image Analysis Framework Over Extended Time Periods

The paper uses a deep-learning framework to analyze shape dynamics of GUVs over time, measuring morphometric changes and budding behavior.

High-throughput, single-cell-encoded colony imaging reveals infection-linked heterogeneity

HeteroTyper quantifies phenotypic heterogeneity in bacterial colonies across multiple media types, revealing tissue-specific differences and growth dynamics during infection.

Context-dependent effects of ketamine on emotional evidence integration

This study examines how ketamine affects emotional evidence integration in changing environments, finding it shifts the balance between recent and past information based on volatility.

Loneliness as a modulator of intersubject neural alignment across social and nonsocial contexts

This study examines how loneliness affects neural synchrony during social and nonsocial tasks, finding idiosyncratic responses in lonely individuals and greater synchrony in specific brain regions.

Species identity rather than colony size partitions shape variation in six Caribbean octocorals

The paper examines colony shape variation in Caribbean octocorals, finding that species identity, not colony size, primarily determines shape differences.

Topographic reference modelling of white matter hyperintensities across the adult lifespan

This paper introduces vTRM, a framework to characterize WMH spatial patterns across age and sex, revealing distinct associations with aging, vascular, and neurodegenerative processes.

Cargo levels control endosomal PI(3)P homeostasis through direct feedback between SNX17 and MTM1

Photoentrainment as Bayesian Inference: How the central circadian clock may weight and integrate the intensity and wavelength of natural light to estimate astronomical time

The paper proposes a Bayesian model explaining how the circadian clock integrates light intensity and wavelength to estimate astronomical time despite natural variability.

Ultradeep optical coherence tomography

This paper introduces ultradeep OCT to image deep brain structures with improved depth and resolution, demonstrating its potential for studying neurodegenerative diseases.

Functional ultrasound imaging in free-moving marmosets reveals that intra-call prosodic features modulate large-scale cortical dynamics

This study uses functional ultrasound imaging in marmosets to show that intra-call prosodic features influence large-scale cortical dynamics during vocal interactions.

Predicting cortical signal mixing in coarse-resolution fMRI: a forward-operator analysis of surface mapping and the conditional benefit of correction

This paper develops a forward-operator model to predict signal mixing in fMRI and shows that correcting for it improves coarse-resolution cortical mapping.

Pain Matters: Nociceptive signaling drives neural encoding of inflammatory responses

The paper shows that nociceptive signaling is essential for the brain to represent and replay inflammatory states using human fMRI and mouse activity mapping.

Calcium and actomyosin pulses drive tricellular zipping to remodel epithelial cell-cell junctions and facilitate cell packing

The paper identifies tricellular zipping as a mechanism for epithelial junction remodeling, driven by calcium and actomyosin pulses, and shows its role in cell packing across Xenopus, mouse, and Drosophila embryos.

Predicting seabird-vessel interactions from bird-borne data alone

This paper develops a method to predict seabird-vessel interactions using only seabird telemetry data, showing high accuracy but limitations in distinguishing fishing from nonfishing vessels.

NTAD: A longitudinal neuroimaging dataset of Alzheimer's disease pathology

The paper introduces a longitudinal neuroimaging dataset of Alzheimer's disease pathology, including multimodal data from patients and controls, to identify and validate novel biomarkers.

Metabolic complexity in the human brain supports metastable network dynamics and declines in normative ageing

This study investigates metabolic complexity in the human brain using PET and fMRI, finding that metabolic entropy correlates with network metastability and declines with age.

Stable large-scale network architecture and structured individual variability in the awake mouse brain

The paper introduces the Awake Mouse Connectome Project (AMCP), a dataset of 212 awake mice, and presents functional network atlases and analysis tools for studying brain connectivity and variability.

Submembrane geography dictates GPCR signalling compartmentation and physiological function

This study shows that GPCR signaling varies based on submembrane location, with different functional outcomes in cardiomyocytes, and introduces submembrane-specific beta-blockers that target specific nanodomains.

Diagnose Harmonisation (DHARM): An open-source tool for the harmonisation and analysis of batch effects in MRI-derived measures.

DHARM is an open-source tool that diagnoses, harmonizes, and evaluates batch effects in MRI data using standardized workflows and multivariate diagnostics.

Neural transformation from image realism to perceived realness

The paper shows that perceived realness is processed in higher dorsal visual areas, not the ventral stream, and is linked to later processing in the intraparietal sulcus.

Mixing, competence, and commitment set the stability of cell identity

The paper models cell identity stability using a Markov framework, showing how mixing, competence, and commitment influence transition rates and proposes experiments to test these mechanisms.

cGAS integrates Toll-like receptor signaling in platelets to promote thromboinflammation

This study shows that cGAS integrates TLR signaling in platelets to drive thromboinflammation by sensing mitochondrial DNA.

Quantum Dot-Based Non-invasive Monitoring of Sinusoidal Endothelial Scavenger Function in Steatohepatitis

This study develops a non-invasive method using quantum dots to assess liver sinusoidal endothelial cell scavenger function in MASH, showing reduced retention correlates with disease progression.

A Comparison and Validation of BIDS Apps for Preprocessing of UCB-J PET data

This study compares and validates two BIDS Apps, PETPrep and PICNIC, against in-house software for preprocessing UCB-J PET data, finding high consistency but region-dependent bias.

Parkinson Disease vs Aging Features Impairments in Formation and Release of a Power Grip in Real and Pantomimed String-Pulling

This study compares movement impairments in Parkinson's disease, aging, and young adults during real and pantomimed string-pulling tasks, identifying differences in speed, workspace, and hand shaping.

Short-term changes in a chicken comb vascular model mimicking port-wine stain after synchronous ultrasound parallel beam treatment: an exploratory study

This study examines the short-term effects of SUPERB ultrasound treatment on a chicken comb model, finding reduced vascular caliber and VEGF-A expression but no consistent collagen changes.

Circuit regulation along an activity continuum shapes flexible and stable representations during learning

The paper identifies mechanisms in the medial entorhinal cortex that balance representational flexibility and stability during learning through excitatory and inhibitory neuronal activity dynamics.

Transplantation of human iPSC-derived retinal cells in the cone-dominant Northern tree shrew

This study transplants human iPSC-derived retinal cells into Northern tree shrews and shows improved survival with a complex immunosuppression treatment.