imaging

Differential effects of chronic hypertension and sex on vascular density along the septotemporal axis of the hippocampus in a rat model of VCID

This study examines how chronic hypertension and sex affect vascular density in different regions of the hippocampus in rats, finding sex-specific changes in vascular structure.

Self-Other Neural Representational Distinction is Associated with Distorted Social Predictions in Social Anxiety

This study investigates how social anxiety affects self-other neural distinctions and social predictions, finding that higher SA correlates with greater self-other representational separation in the pgACC and altered prediction tracking in the precuneus.

Long term survival of chronically demyelinated axons in the taiep rat

The paper examines axon survival in chronically demyelinated taiep rats and finds that small diameter axons can survive for months with increased glial support.

CardioShift: Resolving cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes from high-throughput single-cell imaging

CardioShift resolves cell-to-cell functional heterogeneity in hiPSC-derived cardiomyocytes by accounting for nested variance, revealing hidden subpopulations and condition-dependent phenotypes.

Cerebrovascular Structure-Flow Gradients Revealed by Volumetric Ultrasound Localization Microscopy

This study uses volumetric ultrasound localization microscopy to identify two reproducible gradients of cerebrovascular structure and flow in mice, defining axes of vascular density/flow complexity and flow speed/acceleration.

Strategy-dependent causal relationships between large-scale cortical activity and perceptual decisions

The paper investigates how different decision-making strategies in mice affect cortical activity and identifies frontal cortex involvement in engaged strategies.

Peripheral Axons Form Endoplasmic Reticulum-Rich Conduits With Breast Cancer Cells

The paper identifies ER-rich conduits formed by peripheral axons and breast cancer cells, revealing a structural interface for potential intercellular communication.

Dog and Human Brains Represent Human Emotional Bodies with Asymmetric Encoding of Happiness and Anger

This study shows that dogs and humans have similar neural representations of human bodily emotions, with happiness and anger encoded asymmetrically in distinct brain regions.

Lesion-Derived Estimated Functional and Structural Connectomes Predict Post-Stroke Recovery Outcomes

The paper develops a pipeline to estimate structural and functional connectomes from lesion masks to predict post-stroke recovery outcomes, showing better performance than traditional methods.

ConfUSIus: an accessible and scalable toolkit for functional ultrasound imaging analysis

ConfUSIus provides an open-source toolkit for analyzing functional ultrasound imaging data, unifying processing steps and improving accessibility and reproducibility.

Multimodal longitudinal prediction of alcohol-use trajectories in adolescents and young adults: Social context, real-life social affective benefit, and fronto-striatal involvement

The paper predicts alcohol-use trajectories in adolescents and young adults by analyzing social context, social affective benefit, and fronto-striatal neural involvement over one year.

Light-sheet fluorescence microscopy of optically cleared human head-and-neck organs: three-dimensional tissue assessment and histological correlation

This study uses optical clearing and light-sheet fluorescence microscopy to visualize 3D microanatomy of human head-and-neck tissues and correlate it with conventional histology.

Comparative Oogenesis in Annual and Non-annual African Killifishes: Oocyte Staging in the Fastest-Aging Vertebrate, Nothobranchius furzeri

This study compares oogenesis in annual and non-annual killifishes, finding conserved developmental stages but divergent zona pellucida features in the annual species.

Tissue geometry patterns epidermal stem cell fate in murine interfollicular skin

The paper shows that dermal-epidermal junction geometry influences stem cell fate in mouse skin, with concave areas promoting proliferation and convex areas promoting differentiation.

ADRA2B genetic polymorphism modulates vagus nerve stimulation response

This study investigates how a genetic polymorphism in ADRA2B affects responses to vagus nerve stimulation, finding it influences pupillary responses and cortical activity alignment with noradrenergic projections.

Brain-wide representations of olfactory behavior in C. elegans

The paper analyzes brain-wide neural activity in C. elegans during olfactory navigation and identifies functional circuits linking sensory input to motor behavior across different environments and behavioral states.

PhenoMe: An interactive AI framework for interpretable, microscopy-driven phenotyping

PhenoMe provides an open-source framework for analyzing microscopy images using foundation model-derived embeddings and experimental metadata to enable phenotyping and data exploration.

Establishing an assay for visual desensitization in larval zebrafish for understanding synaptic plasticity

This study develops an assay in larval zebrafish to investigate visual desensitization and its role in synaptic plasticity by measuring escape responses to varying visual stimuli.

Circadian multimodal physiological, ocular and behavioural data from a 40-hour forced-desynchrony protocol

The paper presents a multimodal dataset from a 40-hour forced-desynchrony protocol to study circadian rhythms and their effects on physiology, ocular function, and behavior.

A compact three-way junction oligonucleotide probe for widefield and super-resolution imaging of RNAs and proteins

This paper introduces a compact three-way junction oligonucleotide probe for multiscale RNA and protein imaging, enhancing detection while preserving nanoscale resolution and enabling large-field tissue analysis.

Mucosal ACP subunit vaccine formulated with a small molecule STING agonist drives protective TH1/TH17 responses and serum bactericidal antibodies against Neisseria gonorrhoeae

This study evaluates a mucosal vaccine combining ACP and diABZI, showing enhanced TH1/TH17 responses and serum bactericidal activity against Neisseria gonorrhoeae.

Noise-referenced multi-shell diffusion-weighted imaging for regional cerebrospinal fluid thermometry

This paper develops a diffusion-weighted imaging method to estimate cerebrospinal fluid temperatures in different regions and finds ventricular temperatures are consistently higher than subarachnoid temperatures.

Wearable Estimation of Knee Joint Contact Forces: SiMPLeSENSE, a Simulated-IMU Pipeline Validated Against In Vivo Loads

The paper develops SiMPLeSENSE, a simulated-IMU pipeline that estimates knee joint contact forces using motion capture and EMG, validated against in vivo measurements with high accuracy.

Leg blood flow and muscle oxygenation are reduced when exercising with loads >=40% 1RM compared to loads <=30% 1RM due to increases in contraction induced intramuscular pressure

This study shows that leg blood flow and muscle oxygenation decrease during resistance exercise at loads ≥40% 1RM compared to ≤30% 1RM due to increased intramuscular pressure.

MillionTrees: A global benchmark for tree detection across geography, sensor, and annotation geometry

The paper introduces MillionTrees, a global benchmark dataset for airborne tree detection, showing that current models struggle to generalize across diverse data and that training on MillionTrees improves performance.

MaxCAT-Net: Hybrid Transformer-Based Skin Lesion Classification and Lightweight Segmentation with Calibration and Cross-Dataset Validation

MaxCAT-Net improves skin lesion classification and segmentation with hybrid architecture and calibration, showing performance on benchmark datasets but with preliminary results.

Cross-species structure-mechanics prediction in the intervertebral disc

This study develops a cross-species framework linking collagen structure to mechanical vulnerability in intervertebral discs using multiscale imaging and modeling.

EigenBrain maps cortical molecular architecture from functional, geometric, and structural eigenmodes

The paper shows functional MRI eigenmodes can approximate specific receptor and transporter distributions in the cortex, while structural and geometric eigenmodes cannot, and applies this to detect molecular differences in autism and schizophrenia.

Spatial Decoupling of the Endodermal Functions Establishes the Innermost Cortex as the Gravity Sensor in Rice Stems

The paper identifies a specialized cell layer in rice stems that functions as a gravity sensor, distinct from the lignified endodermis, and shows its role in gravitropic responses through starch sedimentation and auxin signaling.

Decoding stress-induced adaptation of cancer cells in spatial confinement by integrating live-cell imaging and mathematical modeling

This study combines live-cell imaging and mathematical modeling to show how cancer cells adapt to stress in spatially confined environments, revealing cooperative and competitive strategies influenced by spatial organization and microenvironment dynamics.