structural biology

The paper identifies binding-defective SUFU variants by structurally and biochemically analyzing GLI-SUFU complexes and validating key residues involved in their interaction.

This study determines the structural basis of QueC-family protein function in the qatABCD anti-phage defense system, showing their role in targeting protein substrates for N-terminal modification.

This study captures transient states of the ABC transporter TM287/288 using time-resolved small-angle X-ray scattering and reveals a transient occluded state in its ATP-driven conformational cycle.

The paper identifies loop motifs in Myosin1C that determine cellular and organ chirality by swapping these motifs between Myosin1C and Myosin1D and analyzing their effects.

The paper identifies a chicken MHC class II molecule that binds the same viral peptide with both nonamer and decamer core sequences, revealing binding plasticity in immune response to MDV.

The paper investigates how sequence variations in BET ET domains influence paralog-specific peptide recognition through loop dynamics and conformational changes.

This paper develops a stabilized MR1 variant, SMART-MR1, that preserves native-like ligand presentation and TCR recognition while enabling biochemical and structural studies.

The paper investigates how missense mutations in the SynGAP C2 domain affect membrane diffusion dynamics through molecular simulations and structural analysis.

This study reports crystal structures of the QacA efflux pump in different conformational states, revealing structural dynamics and mechanisms of multidrug transport and extrusion.

This study quantifies how Mg2+ modulates the conformational equilibrium of the 7SK RNA SL3 domain, showing a shift toward the SL3e state and identifying a DMS reactivity signature for A*C wobble base pairs.

This study determines the crystal structure of E. coli Nissle 1917 flagellin and shows that hypervariable regions affect motility but not TLR5 recognition.

This study reveals how BCRII enzymes use electron-bifurcation modules to reduce aromatic rings beyond typical biological redox limits.

The paper determines the structural basis of substrate recognition by PafA, showing that broad specificity arises from dynamic, geometrically compatible interactions rather than sequence-specific binding.

This study reveals the pH-driven allosteric mechanism of hexamer glargine using serial femtosecond crystallography and multiscale analyses, showing a structural transition linked to delayed release.

This study investigates how AcrIIC1 inhibits GeoCas9 by analyzing structural and dynamic changes in the HNH nuclease domain.

The paper reports the structures of α-synuclein filaments from individuals with Parkinson's disease and dementia, revealing differences in dimerisation and twist reversal between pathogenic and non-pathogenic variants.

This study identifies a conserved mechanism in green algae where FNR is tethered to PSI-LHCI via Lhca4's N-terminal helix, revealing spatial regulation of electron transfer.

The paper identifies AMI-1 as an inhibitor of NMNAT1, shows its effect on NAD+ levels and cancer cell viability, and determines its binding mechanism via cryo-EM.

This study investigates the biophysical mechanisms underlying anandamide selectivity for CB1 receptors, revealing enthalpic and entropic effects shaped by N-terminus movements and binding pocket volume differences.

This paper reports cryo-EM structures of HIV-1 RT during PPT strand displacement, revealing the mechanism and key residues involved in the process.

This study reports the crystal structure of HIV-1 reverse transcriptase bound to depulfavirine, showing its extended binding conformation and resistance to common mutations, along with combination efficacy with other antivirals.

This study determines the crystal structures of PaIMPase and proposes three Mg2+-dependent catalytic mechanisms based on structural and kinetic analyses.

This study identifies redox regulation of CsoSCA, a carboxysomal carbonic anhydrase, showing it is inactive under reducing conditions and active under oxidizing conditions due to a conserved cysteine pair.

This study determines the structure of the hibernating F. tularensis ribosome and shows RaiA and antibiotics bound to it, offering insights for therapeutic intervention.

This study uses AlphaFold and Markov state modeling to analyze the conformational dynamics of Na+-NQR, revealing how redox state and Na+ binding regulate Na+ translocation.

This paper introduces a method to generate white matter tractograms from FLAIR images without diffusion data, showing it captures structural probabilities similar to diffusion-based tractography.

This paper analyzes the molecular mechanisms of broadly neutralizing SARS-CoV-2 antibodies by combining computational methods to reveal how conserved epitopes resist immune escape.

The paper elucidates the hydrolysis mechanism of Family II inorganic pyrophosphatase using structural and computational methods, identifying a μ-oxo nucleophile as the rate-limiting step.

This study defines the molecular architecture of Influenza A virions using structural and compositional approaches, revealing unique features of filamentous virions.