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This study shows that GluN2A loss specifically impairs excitatory synaptic integration in hippocampal somatostatin interneurons, affecting EPSP decay and firing without impacting pyramidal or parvalbumin interneurons.

This study develops engineered endocrine objects (EEOs) that tolerate hypoxia and enable subcutaneous engraftment in diabetic mice, achieving glycemic control with reduced central necrosis.

This paper demonstrates efficient transient gene delivery into primary Schwann cells using circular RNA delivered by Listeria monocytogenes drones, achieving high bactofection efficiency with minimal cell death.

The paper presents RES-Q, a network of wearable sensors and syringe-implantable autoinjectors for closed-loop therapy, demonstrating rapid overdose rescue in rats.

This study shows that postpartum resource scarcity in rats alters maternal behavior, offspring prioritization, and steroid-sensitive brain region structure.

This study identifies early proteomic changes in cardiac fibroblasts after doxorubicin treatment, revealing ECM and mitochondrial-related proteins associated with early senescence responses.

This study shows that task identity is decoded from population activity in the frontal cortex before task-specific stimuli, with conserved geometric representations across tasks, areas, and individuals.

The paper compares TRN and dLGN receptive field properties across cat and mouse to show spatially and temporally tuned inhibition in sensory processing.

This study shows that silent nociceptors are active during both phases of the formalin test in rats, suggesting their involvement in persistent pain mechanisms.

This study shows maternal e-cigarette exposure increases neonatal ischemic brain injury in rats by disrupting the miR-30c-5p-Neurod1 axis.

This study shows oxytocin modulates auditory processing in macaques differently depending on sensory context, reducing responses in unimodal tasks but increasing them in audiovisual tasks.

This paper introduces local goodness-of-fit measures to assess state-space models in neural decoding, identifying when models poorly fit data during recordings.

The paper develops a Herbivore-Carnivore index to assess diet and health in human gut microbiota, finding humans fall between herbivores and carnivores with diet and health linked to HC-index values.

This study compares HIV-1 gp120 subtypes A and B, showing subtype A induces more severe pulmonary arterial hypertension through enhanced furin activity and different CD4 and nAChR interactions.

The paper compares larval single-cell transcriptomes of sponges and cnidarians to explore the evolutionary origins of neural and sensory cell types.

The paper identifies telotrons, telomeric repeat-containing introns, in multiple eukaryotic genomes and suggests telomerase drives intron creation and remodeling.

This paper introduces a fibrous optofluidic probe for measuring blood oxygenation and flow velocity in vessels, demonstrating its use in rabbit and canine models.

This paper introduces [18F]GPR39 2.1, a PET radiotracer for noninvasive imaging of GPR39, showing high specificity and sensitivity in vivo.

The paper uses pseudo-observations of longevity to identify resilience-associated genes in rhesus macaques exposed to radiation and aging challenges.

The paper compares gene regulatory networks in mouse and pig limb development to reveal conserved and divergent regulatory programs and mechanisms of developmental robustness.

LinearKnot approximates CParty's hierarchical pseudoknot analysis with linear time complexity, achieving comparable accuracy for RNA structure prediction and ensemble calculations.

This study identifies persistent spinal mitochondrial dysfunction and increased mPTP susceptibility as features of chemotherapy-induced neuropathic pain and supports mitochondrial protection as a therapeutic strategy.

This paper uniformly re-analyzes public omics data from exercise studies in humans and rodents, providing standardized effect sizes and meta-analyses across multiple tissues and molecular layers.

The paper identifies a neurochemical signature in the paraventricular nucleus of the thalamus that predicts individual differences in cue-reward learning in rats.

The paper examines altered sensory integration in a rat model of Fragile X Syndrome, finding enhanced visual capture and reduced self-motion processing in the head-direction system.

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

This study shows that intrathecal Shikonin reduces bone cancer pain in rats by suppressing spinal IGF2-associated p38 MAPK signaling, improving pain-related behaviors and reducing inflammation.

This study links ER stress and impaired NAD biosynthesis via QPRT to reduced oocyte quality and shows that NMN supplementation improves oocyte function and early embryonic development.

This study identifies middle ear dysfunction as the primary cause of residual hearing loss in chronically implanted guinea pigs, suggesting a conductive mechanism.

This study shows that neonatal NMDA receptor blockade impairs social affective behavior in rats, linked to reduced parvalbumin interneurons in the medial prefrontal cortex.