transcription & RNA processing

The paper uses live-cell imaging and kinetic analysis to show that transcription initiation efficiency is influenced by Pol II dynamics and the order of pre-initiation complex assembly.

This study presents cryo-EM structures of Mor-TAC and C-TAC complexes, revealing a tetrameric binding mode and interactions with RNAP, elucidating the transcription activation mechanism of phage Mor/C family activators.

This study identifies Stm1's role in promoting ribosome biogenesis by regulating Ifh1 activity, revealing a link between ribosome biogenesis and dormancy.

The paper identifies a cell-controlled pathway generating tRNA-derived small RNAs (tsRNAs) in plant male gametes, which mediate translational repression in pollen grains.

This paper develops a FUS-responsive granular hydrogel system that stabilizes through crosslinking and porosity control, showing potential for minimally invasive tissue regeneration.

This paper introduces a new bioink called microfiber-templated porogel (FTP) bioink that enables the creation of vascularized 3D bioprinted structures with tunable porosity and in-situ endothelialization.

This study shows Sputnik virophage alters APMV gene expression timing, prolonging early and delaying late gene expression, without significantly affecting amoeba gene expression.

This study uses live microscopy to show that Hippo signalling regulates transcription by controlling the DNA dwell times of YAP and TEAD proteins.

This study identifies a transcriptional regulatory module involving MaHSF11 and MaMYBFA factors that regulates flavonol biosynthesis and B-ring hydroxylation in banana.

This study identifies an ISR-independent role of GCN2 in preventing excessive ribosome biogenesis and mRNA translation, with implications for cancer therapy.

This study shows CDK12/13 inhibition disrupts nucleolar structure and causes aberrant IGS rRNA transcript expression due to impaired processing and degradation.

The paper identifies two pathways for RNA 3' end processing in the gal operon: Rho-dependent termination and RNase E-mediated cleavage, which generate pre-galE mRNA 3' ends that are stabilized by a hairpin structure.

This study investigates the roles of Ki-67, GNL2, and MDN1 in ribosome biogenesis and transcriptome regulation in HEK293T neuronal lineage cells, revealing their impact on nucleolar function, pre-60S particle export, and neuronal development.

This study identifies two mechanisms by which RECQ5 modulates RNA polymerase II transcription: attenuating elongation via the brake helix and forming a condensate scaffold matrix.

This paper develops LTGF-β conjugated scaffolds to improve neocartilage development by mimicking native TGF-β activation, achieving better mechanical and biochemical properties compared to conventional TGF-β supplementation.

This study tests the BioAxFlow bioreactor's ability to enhance cell adhesion, proliferation, and maintain osteogenic and tumorigenic properties of SAOS-2 cells in a dynamic culture system.

This study identifies E2F1 as a suppressor of EBV lytic reactivation by regulating transcriptional networks involving BZLF1 and c-Myc.

This study identifies the mechanochemical Piezo1-Erk1/2-Yap1 pathway in multiciliated cells that regulates centriole amplification through tension-dependent activation of Foxj1.

This study identifies early proteasome dysfunction and transcriptional downregulation in Alzheimer's disease, contributing to proteostasis failure and neurodegeneration.

This study shows that EWS-FLI1 expression in human embryonic mesenchymal stem cells leads to an ES-like transcriptome and tumor formation, despite not preferentially binding promoters.

This study shows AR-V7 forms condensates independently of androgens and AR-FL in CRPC, driving oncogenic transcription through both condensate-dependent and -independent mechanisms.

This study develops RIFT, a real-time in-vitro assay to visualize RNAPII transcription, revealing IDR-dependent activation mechanisms and condensate effects on transcription.

This paper introduces a hybrid biomaterial that enhances cell migration and self-assembly in bioprinted constructs, enabling complex tissue-like structures with improved vascular network formation.

This paper develops an injectable hydrogel with antibacterial properties for tissue engineering applications, showing good biocompatibility and ability to form 3D cell aggregates.

This study shows that linker histone H1 in Arabidopsis thaliana maintains rhythmic gene expression by modulating chromatin structure and transcriptional dynamics across the diurnal cycle.

The paper identifies a functional pseudogene, RPS27AP5, that produces ubiquitin and ribosomal protein variants involved in specialized ribosomal functions and transcriptional regulation.

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

This study identifies and characterizes the HSF gene family in Rhodomyrtus tomentosa, revealing subfunctionalization in RtHSFA2 subfamily and highlighting RtHSFA2b's role in thermal adaptation.

This paper develops hydrogels with continuous viscoelastic gradients to study cell migration influenced by local viscosity and elasticity rather than stiffness.

The paper shows genome concentration limits transcription and affects proteome composition in E. coli, with effects detectable in nutrient-rich conditions.