T-cell and B-cell Immunology

The paper analyzes the αβTCR repertoire across 734 mouse samples to uncover patterns in TCR diversity, non-random joining, and clonal expansion.

This study shows that B cell v integrin limits GC activity and memory B cell expansion in the lung after IAV infection, suggesting it as a target for improving mucosal vaccines.

This study identifies SATB1 as a regulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells, showing its potential as a target for CAR T cell therapy.

This study shows that lifelong self-renewal and competition shape the aging of virtual memory CD8 T cells, leading to a dominance of long-lived resident cells.

The paper identifies location-specific transcriptional differences in tumor-infiltrating Treg cells across CRC metastases and links these to poor patient prognosis.

The paper shows that combination adjuvants drive Th17 cells that convert to multi-functional Th1 cells, enhancing antifungal immunity in mice.

BenchRep-T evaluates nine T-cell repertoire methods across four tasks, finding simple baselines competitive with complex models and no single method dominates all tasks.

This paper identifies a feedback mechanism where Vγ1.1Vδ6.3 T cells are reprogrammed into ILC1-like cells to restrain autoimmune pathology.

This study shows that BCR ligation selectively inhibits IgE class switch recombination in mouse and human B cells, with synergistic effects from IL-21 and TGFβ1.

This study shows that co-immunizing with adenosine deaminase and a DNA vaccine improves T follicular helper cell function and antibody quality in aged mice, enhancing protection against C. difficile infection.

This study identifies distinct transcriptional programs in human IgG4+ memory B cells, revealing unique features and potential therapeutic targets.

This paper introduces a 50-marker mass cytometry panel to comprehensively profile functional diversity in human immune cells, detecting cytokines and chemokines beyond traditional panels.

This study evaluates how CD8/CD4 coreceptors affect T cell function by analyzing TCR-pMHC catch and slip bonds, finding that coreceptors enhance bond metrics and TCR sensitivity and specificity.

This study identifies CD96 as the dominant mediator of CD155 internalisation in human T cells through receptor cycling and variant-specific differences.

This study identifies antigen-reactive CD4+ T cells after SARS-CoV-2 vaccination using single-cell RNA and TCR sequencing, revealing phenotypic differences between stimulated and unstimulated states.

The paper shows preselection CD4+CD8+ thymocytes undergo gene expression changes linked to reduced TCR responsiveness and impaired CD4 fate gene upregulation, connecting these changes to T cell lineage commitment.

This study identifies age-related defects in CXCL13+ T follicular helper cells in human tonsil organoids, linking them to reduced antibody responses.

The paper shows that human IgE+ plasma cells are selectively killed by BCR crosslinking due to a JNK/PTEN/BIM signaling axis, distinct from mouse mechanisms, and highlights therapeutic implications for anti-IgE antibodies.

This study investigates how booster immunizations affect germinal center (GC) clonality in mice, finding that refueling leads to clonal expansion rather than memory recruitment.

UcTCRp profiles MAIT- and iNKT-associated immune states using TCRβ sequences without requiring single-cell data or antigen-specific markers.

The paper develops a multiplex phosphoflow assay to profile age- and immune cell-specific signaling activation in 18 subpopulations, revealing distinct patterns in healthy individuals aged 1-69 years.

This study shows ACLY links metabolism to chromatin accessibility in B cells, essential for activation and humoral immunity.

This study identifies the MHC-I alpha3 domain-CD8 interaction as an inhibitory pathway that restrains CD8+ T-cell activation and maintains tolerance in vivo.

This study shows that inhibiting NKCC1 with bumetanide does not affect plasma cell survival, persistence, or antibody secretion in vitro and in vivo.

The paper identifies and characterizes distinct B cell subsets in the human thymus, revealing their development, differentiation, and class switching capabilities.

This study identifies TRIF and IL-1R1 as regulators of intestinal IgA production, showing their roles in controlling IgA class-switching and germinal center B cell differentiation.

This study identifies fibroblast-derived TGF-β3 as a critical factor sustaining CD8+ TRM in barrier tissues and tumors, showing its role in survival and function.

AbSolution enables integrated analysis of sequence-derived features in immune repertoires across datasets and conditions.

This study identifies a hierarchical mechanical force-based model of Treg suppression, showing that stable adhesion is required for localized cytokine delivery to dendritic cells.

This study shows that age-dependent PD-1 induction limits IL-2-driven effector T cell responses during La Crosse virus infection in mice, leading to impaired viral control.