Osteoarthritis Treatment and Mechanisms

Anatomically matched spatial comparisons identify Trps1 as a regulator of knee interzone formation

The paper identifies Trps1 as a regulator of knee interzone formation through spatial comparisons and perturbation experiments in mice, showing its role in chondrogenic differentiation.

Single-nucleus multiome profiling reveals osteocyte-centered remodeling of human subchondral bone across osteoarthritis severity

The paper uses single-nucleus multiome sequencing to analyze subchondral bone in OA, finding increased osteocyte SMAD2/3 activity and chondrocyte-derived FN1 signaling with disease severity.

Tropomyosin 3.1 Regulates Chondrocyte Cortical F-actin Stability and Homeostasis

This study investigates how Tpm3.1 stabilizes cortical F-actin in chondrocytes and how its loss drives catabolic gene expression through YAP and MRTF.

N-Acetylglucosamine ameliorates knee osteoarthritis by enhancing UDP-GlcNAc conversion and chondrocyte DNA repair capacity

This study compares N-acetylglucosamine (GlcNAc) and glucosamine hydrochloride (GlcN·HCl) in a rat model of knee osteoarthritis, finding GlcNAc more effective in reducing inflammation, cartilage degradation, and promoting DNA repair.

Pathological musculoskeletal characterisation of a new model of spontaneous OA in CD1 mice.

This study characterizes spontaneous OA in CD1 mice, showing progression from mild to severe disease with multi-tissue pathology, establishing them as a robust model for OA research.

Protein Response to ACL Injury in Humans Show Early Cartilage Remodeling and Sex-Specific Effects

The paper identifies sex-specific protein responses in human cartilage after ACL injury, showing early remodeling and differences in inflammation, metabolism, and ECM pathways.

PIEZO1 mediates mechanosensing and myofibroblastic activation of synovial fibroblasts in post-traumatic osteoarthritis

This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.

Mechano-activated synovial cells instigate OA-like disease progression in the absence of joint injury

This study shows that altering synovial cell mechanotransduction drives OA-like disease without joint injury, with partial effects on symptoms versus structural damage.

Nose-to-Knee Transplantation for Osteochondral Regeneration: A Proof-of-Concept Study in Sheep Employing Ceramic-Hydrogel Osteochondral Grafts

This study develops autologous osteochondral grafts in sheep using nasal chondrocytes and 3D-printed scaffolds, showing mechanical maturity but limited integration due to implant sinking.

Loss of KMT2D accelerates hypertrophic chondrocyte differentiation and senescence by increasing mitochondrial ROS production

This study shows that KMT2D deficiency causes chondrocyte hypertrophy and senescence via increased mitochondrial ROS, leading to skeletal abnormalities in KS1.

Benchmarking longitudinal local centiles for radiographic knee osteoarthritis prognosis

This paper benchmarks longitudinal local centile maps for predicting radiographic knee osteoarthritis progression using MRI data.

Benchmarking cartilage regeneration across ten chondrogenic cell sources using native tissue references

This study benchmarks ten chondrogenic cell sources for cartilage regeneration using native tissue references, finding mesenchymal stem cells and fetal chondroprogenitors perform best.

Inhibition of hexokinase 2 undermines cartilage health and accelerates osteoarthritis

This study shows that inhibiting hexokinase 2 (HK2) impairs cartilage formation and accelerates osteoarthritis progression in mice.

Injury Causes Altered Metabolism including O2 Consumption in Bovine and Human Chondrocytes

This study examines how mechanical injury alters metabolism in bovine and human chondrocytes, revealing differences in oxygen consumption and glutamine accumulation between healthy and osteoarthritic cells.

Mapping the response of primary human chondrocytes to an osteoarthritis-relevant stimulus by single-cell RNA sequencing

This study uses single-cell RNA sequencing to analyze how fibronectin fragment treatment alters chondrocyte states and transcriptional programs in primary human cells.

Enhancing the hyaline cartilage regenerative potential of induced pluripotent stem cell-derived chondrocyte cell sheets

This study demonstrates that iPS cell-derived chondrocyte sheets can regenerate hyaline cartilage in vivo when cultured under low-serum and hypoxic conditions.

Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis

This study shows that microarchitectural features of articular calcified cartilage in mice predict abnormal strain distributions in osteoarthritis.

Identification of Mitochondrial-Lipid Metabolism-Related Diagnostic Targets in Osteoarthritis: Integrative Multi-omics Data and Experimental Validation

This study identifies six mitochondrial-lipid metabolism-related hub genes as potential diagnostic biomarkers for osteoarthritis using multi-omics data and experimental validation.

MiRNA Atlas: A Literature-Derived Database of MicroRNAs Bridging Osteoarthritis and Appendage Regeneration

The paper constructs a literature-derived miRNA atlas linking osteoarthritis and appendage regeneration, identifying shared miRNA families and proposing therapeutic candidates.

Combined Cartilage Thickness and Mechanical Property Mismatch Drives Local Strain Amplification at the Patellar Osteochondral Allograft Interface

This study shows that mismatch in cartilage thickness and mechanical properties at the patellar osteochondral allograft interface leads to localized high-strain regions that may cause graft failure.

FERMT2 expression in human articular chondrocytes is regulated by hypoxia-associated transcriptional programs

This study identifies hypoxia as a regulator of FERMT2 expression in human chondrocytes, showing it enhances FERMT2 without adverse effects on ECM, while other factors like GATA1 and MEF2A also influence its expression.

Restoring the Chondron: Pericellular Matrix Reconstitution Enhances Mechano-Inflammatory Resilience and Modulates Chondrocyte-Neuron Crosstalk

This study shows that reconstituting a collagen VI-rich pericellular matrix in chondrocytes reduces inflammatory and mechanical stress responses and modulates neuron interactions.

The Leiden ex vivo human growth plate model in severe tall stature: a proof-of-concept study

This study demonstrates the feasibility of establishing an ex vivo human growth plate model using tissue from percutaneous epiphysiodesis procedures to study bone growth and pediatric growth disorders.

iPSC-Derived Chondroprogenitors as a Promising Cell Source for Cartilage Engineering: A Comparison with MSCs in Unmodified and Peptide-Functionalized Alginate Hydrogels

This study compares chondrogenic differentiation of iPSC-derived chondroprogenitors (iCPs) and MSCs in alginate hydrogels, finding iCPs show superior cartilage formation with enhanced matrix composition.

Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis

This study shows that targeting macrophage connexin 43 hemichannels reduces synovial inflammation and slows osteoarthritis progression in mice and human cells.

TLR-mediated activation of synovial fibroblasts from osteoarthritis patients promotes chondrocyte dysfunction

This study shows that TLR activation in OA synovial fibroblasts leads to inflammatory responses and chondrocyte dysfunction.

Human knee osteoarthritis patient-specific cartilage-on-a-chip model captures donor differences to stressors and treatments

This paper develops a patient-derived cartilage-on-a-chip model for KOA that captures donor differences in response to stressors and treatments.

Targeted analysis of chondrocyte central metabolites in response to cyclical compression and shear deformations

This study investigates how cyclical compression and shear deformations affect central metabolites in chondrocytes, showing changes in metabolites that could inform therapeutic mechanotransduction for cartilage repair.

Inhibiting nociceptor endocytosis reduces MIA-induced osteoarthritic pain behavior

This study shows that inhibiting nociceptor endocytosis with a lipidated peptide reduces MIA-induced osteoarthritic pain behavior in mice and rats.

Protective Effects of Boric Acid Against LPS-Induced Inflammation and Apoptosis in a Primary Human Chondrocyte Model of Osteoarthritis

This study shows that boric acid protects human chondrocytes from LPS-induced inflammation and apoptosis by reducing gene expression, membrane damage, and cell death.