Antifungal resistance and susceptibility

This paper shows EGFR signaling is essential for host defense against invasive aspergillosis, as its inhibition worsens infection outcomes in immunosuppressed mice.

The paper identifies Als5 and Scf1 as complementary adhesins in Candida auris that promote cell-cell interaction and biofilm formation through functional redundancy.

This study identifies Hog1 MAP kinase as essential for Candida auris skin colonization and intradermal persistence through RNA-seq and phenotypic analyses.

The paper identifies genetically diverse Candida albicans strains in blood cultures that differ in echinocandin tolerance and virulence, with implications for antifungal treatment.

This paper identifies the riboflavin biosynthetic pathway as a novel antifungal target in Candida species, showing that key enzymes are essential and that riboflavin uptake mechanisms differ among species.

This study introduces the thermotolerant Arabian killifish as a new model to assess C. albicans virulence at human-relevant temperatures, showing temperature-dependent virulence and drug response.

The paper evaluates 4,000 Erg11 variants to determine azole resistance and fitness costs, finding 33% resistance, 88% cross-resistance, and minimal fitness cost.

The paper identifies mefloquine analogs with broad-spectrum antifungal activity, effective against Candida auris in vivo.

This study sequenced the genome of the fungal pathogen Aspergillus lentulus and predicted azole resistance genes through genomic analysis and comparative genomics.

This study identifies genetic and metabolic adaptations in pan-drug resistant Candida auris strains that enable resistance without fitness costs.

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.

This study examines strain variation in a non-pathogenic fungus, identifying factors linked to virulence differences across strains.

This study shows that sinefungin, a nucleoside analog, reduces the pathogenicity of C. albicans by impairing hyphal growth, biofilm formation, and adhesion to human cells without harming human cells.

This study shows how azole resistance in Candida albicans evolves through copy number variation followed by KSR1 loss of heterozygosity, resulting in a >500-fold resistance increase.

This study shows glucocorticoids increase susceptibility to Aspergillus fumigatus infection by suppressing NF-κB-mediated neutrophil control of hyphal growth in zebrafish larvae.

This study identifies synthetic peptide mimics that kill Candida albicans and synergize with caspofungin to prevent infection, showing efficacy in vitro and in vivo without resistance development.

The paper analyzes 312 Aspergillus clinical isolates from Iceland over 7.5 years to assess species distribution and cyp51A mutations linked to azole resistance.

The paper characterizes a Candida auris outbreak in Spain over five years, finding all isolates belong to clade III, share resistance mutations, and are phenotypically identical, suggesting a single origin and transmission.

This study identifies ERG251 mutations that confer azole tolerance and pleiotropic effects on stress responses and filamentation in C. albicans.

This study evaluates psoriasin's ability to inhibit Candida albicans growth on denture bases, finding it effectively eradicates fungal growth when applied to the material.

This study identifies eburicol accumulation as the mechanism by which azoles exert fungicidal effects against Aspergillus fumigatus, distinct from their action in yeasts.

This study uses Tn-seq to analyze genetic and epigenetic variation in Candida glabrata strains, revealing structural differences, resistance mechanisms, and subtelomeric chromatin accessibility.

This study identifies Erg3 and Erg6a as key enzymes in the ergosterol biosynthetic pathway of Mucor circinelloides, showing their roles in antifungal drug resistance and virulence.

This study shows that brilacidin enhances ibrexafungerp's antifungal effect against Aspergillus fumigatus, including strains resistant to caspofungin.

This study identifies ZCF13 in Candida albicans as a regulator of ribose metabolism that enhances synergistic virulence with Staphylococcus aureus during intra-abdominal infection.

The paper identifies common amino acid substitutions associated with azole resistance in Candida species by analyzing 2,222 resistant substitutions from literature.

This study identifies Zcf27 and Zcf4 as distinct regulators of ergosterol gene expression in C. glabrata, showing their roles in azole resistance and hypoxic adaptation.

This study shows that aripiprazole, an atypical antipsychotic, worsens outcomes of disseminated Candida albicans infections in mice but has minimal effects on fungal growth or gene expression.

This paper shows bisphosphonates like zoledronate enhance azole antifungal activity against dermatophytes and molds, prevent resistance, and could be repurposed for clinical use.

This study evaluates the antifungal efficacy of natural and synthetic antiseptics against Candida auris using an in vitro broth microdilution assay, finding several natural products effective at low concentrations.