Lipid Membrane Structure and Behavior

The paper introduces TXTL-QCMD, a method to dynamically characterize membrane-interacting proteins without purification or labeling, revealing insights into IIMP-membrane interactions.

This study develops organelle-targeted Laurdan probes to measure membrane packing heterogeneity and responses to saturated lipid stress in specific cellular compartments.

The paper uses simulations to show that Sec23 and Sec24 act as spacers to determine the shape of COPII-coated membrane buds by dispersing Sar1 protomers.

This study uses molecular dynamics simulations to compare phosphatidylcholine membrane properties between pure and cancer model membranes, finding differences in surface area, chain order, and bilayer thickness.

The paper introduces a solvatochromic probe, C3L, to measure membrane order at the plasma membrane leaflet level, revealing asymmetry and local modulation by transbilayer interactions.

The paper investigates fluorescence quenching in lipid bilayers using FLIM and finds varying quenching behavior among fluorophores, supporting a transfer-to-trap mechanism with concentration-dependent trap formation.

The paper uses polarizable molecular dynamics simulations to quantify how induced dipole effects influence small molecule permeation through a model phospholipid bilayer, comparing results with nonpolarizable simulations.

This study shows how changing membrane properties can control self-organizing Min protein patterns, revealing their dependence on membrane affinity and lipid composition.

The paper introduces a faster-diffusing LPS model for Martini 2 and completes the Martini 3 LPS toolkit, enabling better simulation of membrane interactions and dynamics.

This paper uses machine learning and simulations to study how aminosterols bind to neuron-like membranes, showing accurate predictions matching experimental data.

This study investigates how bacterial extracellular vesicles interact with host lipid membranes, showing they increase membrane fluidity and preferentially bind to liquid-disordered regions.

This paper investigates how the cytoplasmic tail of P0 affects lipid membrane morphology and describes the production of full-length P0 for further study.

The paper shows that mammalian cells maintain a constant surface area-to-volume ratio as they grow by increasing plasma membrane folding.

This study examines how mixed lipid membrane composition affects proton transfer properties, finding that defects in the membrane structure influence proton diffusion and geminate recombination.

This study uses molecular dynamics simulations to analyze how intrinsically disordered regions of small GTPases interact with membranes, showing that lipid sequence complementarity and electrostatic interactions influence conformational dynamics and lipid sorting.

This study develops a reverse micelle fragment screening method to identify non-covalent ligands for membrane-bound GPx4, revealing ligandability at the protein-membrane interface.

This paper introduces the Freestanding-Bilayer Microscope (FBM) for single-molecule imaging of membrane proteins and benchmarks it against TIRF imaging to study ion channel dynamics.

The paper uses calcium-induced hemifusion to create asymmetric GUVs and studies phase behavior changes, finding variability in outer leaflet exchange and correlation with asymmetry.

This study shows that variance in curvature sensitivity of lipids affects membrane stiffness, with coarse-grained models showing greater softening due to clustering.

This study shows that reovirus capsids deform host membranes in a cholesterol-dependent manner, leading to membrane rupture and viral entry.

This study evaluates modified Nile Red dyes for super-resolution imaging of membrane packing in cells, finding differences in membrane structure between healthy and NPC1 disease fibroblasts.

This study compares the membrane scission capabilities of viral and eukaryotic proteins using mechanical models and SAXS data to analyze how lipid composition and interfacial tension affect neck size.

This study uses molecular dynamics simulations to investigate how acidic sphingomyelinase interacts with lysosomal membranes and how cation amphiphilic drugs like ebastine affect these interactions.

This paper demonstrates the manipulation of encapsulated artificial membranes using lysolipid concentrations to control their structure and properties.

This paper shows that ergosterol mediates natamycin aggregation in yeast plasma membranes, which underlies its antifungal activity and can be enhanced by sphingolipid inhibitors.

This study shows serotonin enhances vesicle association and fusion with lipid bilayers by altering their mechanical properties through water content changes.

This study uses molecular dynamics simulations to investigate how hydrophobic mismatch affects the lateral sorting of transmembrane peptides by analyzing free energy profiles and peptide orientation.

This study investigates the structural and functional dynamics of Staphylococcus aureus α-hemolysin during membrane interaction, revealing its role in cell necrosis and pore formation.

This study evaluates polarizable lipid force fields against experimental data and finds non-polarizable models often perform better despite higher computational cost.

This paper develops a machine learning approach to identify phase-separated lipid domains in cryo-EM images with high accuracy.