Microtubule and mitosis dynamics

The paper uses phylogenetic analysis and structural modeling to study the evolution of cytokinesis regulators in Metazoa and their role in multicellularity.

This study shows Ki-67 switches from repelling to attracting chromosomes during mitotic exit, forming a liquid-like coat that drives chromosome clustering through phase separation.

This study shows that in Candida albicans, dynein (Dyn1) and kinesin-5 (Kip1) work together to drive spindle elongation during anaphase, with Dyn1 compensating when Kip1 is absent.

The paper predicts eukaryotic flagellar beat patterns from molecular chemomechanical parameters using a nonlinear reaction-diffusion model, revealing new mechanisms for wave propagation and biophysical insights.

The paper shows that spatial regulation of the APC/C at mitotic chromosomes enables rapid Cyclin B1 degradation, ensuring proper cell division and genomic stability.

This study shows that B-type plexins regulate mitosis by modulating RanGTPase activity, leading to chromosomal instability and potential cancer progression.

This study reveals the architecture and flexibility of native kinetochores using structural analyses of purified kinetochores from thermophilic yeast.

This study identifies a mechanism by which Centrocortin mRNA is co-translationally localized to centrosomes via dynein, microtubules, and a conserved dynein-binding motif.

The paper shows that spindle architecture limits karyotype evolution in budding yeast by demonstrating that chromosome fusions are tolerated until a critical centromere number is reached.

This study identifies a checkpoint-independent role for Mad3BUBR1 in promoting homolog alignment during meiosis I through its interaction with Stu1CLASP.

This study shows PLK-1 phosphorylation regulates MEX-1 polarization in C. elegans zygotes, similar to its role in POS-1 segregation.

This study shows that Aurora B and KKT14 form an unconventional regulatory pathway controlling mitotic exit and chromosome segregation in trypanosomes.

The paper shows that microtubules and actin filaments guide nuclear movement in Marchantia spores to establish cell polarity before division.

The paper uses cryoET to show cofilin-bound F-actin within platelet microtubules, revealing physiological actin-microtubule hybrids formed under mechanical stress.

This study shows that 14-3-3 proteins in yeast are essential for kinetochore integrity and proper chromosome segregation during mitosis.

The paper investigates the roles of tubulin concentration during prometaphase and Ran-GTP during anaphase in C. elegans meiosis, finding that tubulin concentration may promote spindle assembly near chromosomes.

This study identifies the spatio-temporal roles of AURKA in mouse oocyte meiotic spindle formation using genetic and imaging approaches.

The paper identifies a novel dynamic site of Plk1 recruitment to the inner centromere during mitosis, regulated by Cdk1 and counteracted by Bub1/PP2A.

This study identifies a protein complex involving delta-tubulin, epsilon-tubulin, and TEDC1/2 that is essential for centriole architecture and function.

This study shows that APCCdh1-mediated degradation of Cdh1 is essential for proper meiotic chromosome segregation in S. cerevisiae.

The paper identifies PP2A-B55alpha,delta phosphatase as counteracting Ki67-dependent chromosome individualization during mitosis in mice.

This study shows that insulin signaling delays mitosis in C. elegans germline stem and progenitor cells in a non-autonomous manner, while caloric restriction affects mitosis through AMPK.

This study identifies APLF as a kinase in mouse embryonic stem cells that regulates centrosome number through PLK4 phosphorylation and FHA domain ATP binding.

The paper introduces a computational method, IFTA, to analyze fluorescent speckle microscopy data, revealing new insights into cytoskeletal dynamics in mitotic spindles and actin convergence zones.

This study shows that the Pkd2 channel regulates myosin II and actin recruitment to the cytokinetic contractile ring in fission yeast, suggesting a calcium-dependent mechanism.

The paper identifies cell type-specific differences in cytokinesis regulation in C. elegans embryos using temperature-sensitive mutants.

This study investigates the molecular evolution of the kinetochore complex across primate and rodent species, finding adaptive evolution in many core components and highlighting the role of centromere features in driving protein evolution.

The paper shows that MAPK Pmk1 in fission yeast inhibits APC/C activation by phosphorylating and degrading Slp1Cdc20 under stress, revealing a conserved regulatory mechanism.

The paper quantifies mitotic error correction dynamics in human cells and validates a model explaining error reduction and anaphase timing.

This study identifies a proximity-based activation mechanism where MPS1 phosphorylates AURORA A kinase to enhance error correction during mitosis.