Microtubule and mitosis dynamics

The paper shows that cortical pulling forces misalign the mitotic spindle with the cell's long axis, but an actomyosin-based cell rotation corrects this, aligning the spindle with the long axis, thus fulfilling Hertwig's rule.

This study identifies specific domains of SPC105R critical for meiosis I chromosome segregation in Drosophila oocytes by analyzing its functional regions and interactions.

The paper engineers an allosteric switch in kinesin-1 motors using de novo peptides, showing increased transport in cells through conformational changes.

The paper identifies proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytes using an RNAi screen, finding Brahma and Pumilio as key regulators.

This study identifies CEP41 as a microtubule-stabilizing protein that regulates microtubule assembly and cell proliferation, with implications for ciliopathies.

The paper shows TANGLED1 is recruited to cell plate fusion sites independently of the preprophase band during cytokinesis in maize.

This study identifies KKT14-KKT15 in kinetoplastids as divergent orthologs of Bub1/BubR1-Bub3, suggesting a unique mechanism for chromosome segregation fidelity in trypanosomes.

The paper investigates how molecular torques balance spindle twist during anaphase in human cells, identifying factors that increase or decrease twist.

This study uses MINFLUX to analyze kinesin-1 dynamics in neurites, identifying ATP-binding states and microtubule switching behavior.

This study shows that microtubule dynamic instability is sensitive to specific viscogens, with glycerol having a distinct effect compared to other viscogens.

The paper shows that katanin, kinesin-13, and ataxin-2 prevent premature interaction between maternal and paternal genomes in C. elegans zygotes by limiting sperm content movement and maintaining cohesion.

This study shows that nitrogen availability and TOR signaling improve mitotic fidelity in fission yeast, even when lipid metabolism is disrupted, by mechanisms unrelated to lipid restoration.

The paper shows FOXM1 and CENP-F coordinately regulate G2/M gene expression, specifically affecting chromosome stability in cancer cells.

The paper investigates the role of epsilon tubulin (TUBE1) in microtubule-based structures during male germ cell development in mice, showing its essential function and link to male sterility.

The paper identifies a communication hub involving Mps1 and Aurora B kinases that regulates kinetochore-microtubule attachment through interactions with Ndc80c and Dam1c.

The paper shows that Ipl1/Aurora B kinase regulates Mps1's release from kinetochores by competing with Dam1 for binding to Ndc80:Nuf2, enabling proper chromosome segregation.

This study shows that CnSlu7 ensures proper nuclear positioning during mitosis in Cryptococcus neoformans by regulating splicing of cell cycle and cytoskeletal genes.

This study shows that phosphatidic acid recruits specific motor proteins to lipid bilayers, enabling in-vitro motility and revealing mechanisms of cargo transport and direction reversal.

This paper identifies ADP release as a rate-limiting factor in kinesin-microtubule binding using experimental data and computational models.

The paper shows that elastic mitotic tethers can generate backward forces on chromosomes even when spindle microtubules are inhibited.

The paper demonstrates that partial lysis of crane-fly spermatocytes during anaphase preserves tether function, allowing biochemical study of mitotic tethers.

The paper shows UNC-10/SYD-2 links kinesin-3 to RAB-3-containing vesicles without the motor's PH domain, enhancing transport and strengthening weak motor-lipid interactions.

The paper identifies a phosphate-binding pocket in cyclin B3 critical for XErp1/Emi2 degradation in meiosis I, preventing premature oocyte arrest.

This study shows that specific mitotic events drive cytoskeletal remodeling necessary for Left-Right Organizer development in zebrafish.

The paper identifies that MARK2 phosphorylates KIF13A to regulate dendritic transport of transferrin receptor-containing vesicles by promoting dissociation from vesicles and preventing axonal transport.

The paper identifies PIE-1 and POS-1 as germ fate determinants that protect P2 germ precursor cells from cytokinesis failure by reducing septin and anillin levels at the division plane.

This study shows that transient lagging chromosomes in anaphase, caused by loss of WDR62 and ASPM, lead to impaired cell proliferation and primary microcephaly through Aurora-B-dependent activation of 53BP1 and p21.

This study shows that PAN2-PAN3 deadenylase activity is required for mitotic robustness under microtubule stress in yeast and human cells.

The paper shows that combining two Anillin mutants rescues cytokinesis defects, revealing uncoupled cytoskeletal roles mediated by Anillin's N- and C-termini.