Autophagy in Disease and Therapy

LIRcentral is a manually curated database of experimentally validated LIR-motifs, providing resources for wet lab and computational research on autophagy-related proteins.

This study examines how aging affects autophagosome formation and maturation in murine neurons, finding reduced formation but increased maturation in aged neurons.

This study identifies GAK/dAux as a regulator of glial autophagy, showing it interacts with ULK1/Atg1 and modulates autophagosome formation and flux.

This study identifies CLA-1L's role in regulating ATG-9 trafficking and presynaptic autophagy through interactions with endocytic proteins.

This study investigates the role of BCL2L13 and autophagy in mtDNA purifying selection by analyzing knockout models in mice.

This study shows autophagy is essential for maintaining CNS myelin homeostasis by degrading myelin proteins like PLP and MBP in oligodendrocytes.

This study isolates and characterizes autophagic bodies from yeast to identify autophagy cargos and examine cargo selectivity.

The paper investigates transcriptional regulation of autophagy by identifying differentially expressed genes and their association with neurodegenerative pathways in response to autophagy induction.

The paper investigates the relationship between autophagy and endocytic pathways in neuronal axons, finding they are distinct but parallel, with pathogenic -synuclein promoting their merging.

This paper develops a framework to measure autophagy rates under non-steady state conditions and applies it to study temporal responses to rapamycin and wortmannin treatments.

This study shows that Exoc5 ablation disrupts autophagy in urothelial cells, activates non-canonical NF-κB signaling, and leads to ureter obstruction.

This study identifies MTMR5 as a neuron-specific autophagy suppressor, showing its role in limiting autophagy and its potential as a therapeutic target for neurodegenerative diseases.

The paper shows that the yeast exportomer complex inhibits Atg36 phosphorylation to prevent pexophagy, revealing a mechanism linking organelle biogenesis to autophagy regulation.

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

This study compares exercise-induced changes in autophagy markers in human and rodent skeletal muscle, finding differences in LC3B-II protein levels and autophagy flux responses.

The paper shows that Pink1 mRNA is transported with mitochondria and tethered by SYNJ2BP and SYNJ2 to support local mitophagy in neurons.

This study shows that SB202190 activates PERK, which enhances TFEB activity and the autophagy-lysosomal pathway, reducing amyloidogenesis in neurodegenerative diseases.

This study identifies ATG-9 trafficking as a mechanism linking presynaptic autophagy to the synaptic vesicle cycle in C. elegans.

This study shows that DIM induces apoptosis and autophagy in fission yeast in a dose-dependent manner, with autophagy contributing to cell survival against DIM.

This study shows that TBCK mutations impair mitochondrial quality control via lysosomal dysfunction, correlating with neurodegeneration severity.

This study shows that KANSL1 deficiency leads to oxidative stress-induced autophagy, causing synaptic dysfunction and neuronal network impairments in neurons.

This study shows that LC3B phosphorylation by STK4 regulates FYCO1 binding and directional transport of autophagosomes, switching their movement from retrograde to anterograde under starvation conditions.

This study identifies Gpnmb as a modifier of lysosome function in macrophages using QTL analysis in an AKR/JxDBA/2J intercross, showing its impact on proteolysis but not cholesterol metabolism.

This study shows that V-ATPase inhibition reduces tumor growth and restores autophagy in a Drosophila glioma model and human glioblastoma neurospheres.

This study shows that autophagy genes atg7 and beclin1 are critical for energy metabolism and survival during the larval-to-juvenile transition in zebrafish, as their loss leads to early death due to metabolic stress.

This study shows that stigmasterol protects hippocampal neurons from hypoxia-reoxygenation injury by inducing mitophagy through LXRβ activation.

This study shows that neuronal autophagy regulates axonal ER calcium stores to control neurotransmission and postnatal viability in mice.

The paper shows that ATP/ADP levels and autophagy interact to regulate neuronal migration by controlling cell pausing and focal adhesion recycling in mice.

The paper assesses ULK1 kinase alterations across 30+ cancer types using -omics data and structural analysis, finding downregulation in gynecological tumors and significant mutation impacts on protein stability.