Heat shock proteins research

The paper visualizes the nucleation, condensation, and propagation of β-tubulin folding in the chaperonin TRiC, showing a hierarchical process involving nonnative structures and TRiC subunits.

This study investigates the function of CDJ5 in Chlamydomonas reinhardtii by comparing its proxiomes with and without a functional 4Fe-4S cluster, revealing its role in chloroplast microcompartment localization and photosynthetic processes.

This study uses smFRET to analyze conformational dynamics of FicD's TPR motifs, showing equilibrium between TPR-in and TPR-out states influenced by ATP and BiP.

The paper identifies Arg80 as a key regulator of proteostasis in S. cerevisiae, showing its role in mitigating proteotoxic stress through interactions with arginine metabolism and stress response pathways.

The paper identifies specific regions in TilS proteins that determine Hsp90 dependence by comparing bacterial orthologs and their interactions with proteases.

This paper identifies a chaperonin complex in malaria parasites that regulates apicoplast proteostasis and shows its potential as an antimalarial drug target.

This study shows that sorbitol corrects chromosome cohesion and translational defects in cohesin mutants by reducing ER stress and protein misfolding.

This study shows chaperones modulate enzyme activity in native states, expanding their role beyond protein folding.

This study shows heat-induced phosphatidylserine (PS) increases drive HSPA1A's plasma membrane localization, with PS synthesis inhibition reducing this localization.

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

The paper identifies new enzymatic activities of GroEL/Hsp60 proteins, including thioesterase and esterase functions, and links these to palmitoylation and antibiotic resistance in M. tuberculosis.

This study identifies HSP70 homologs in diverse viruses, revealing multiple evolutionary origins and functional adaptations.

This study investigates how Hsp110 enhances Hsp70's disaggregation activity through entropic pulling by increasing effective volume.

This study shows bacterial Hsp90 stabilizes megasynthases required for virulence factor production in E. coli and P. aeruginosa.

The paper shows that chaperone saturation limits protein folding homeostasis when translation efficiency is high, revealing mutual sensitivity between translation and folding efficiency.

This study defines proteostasis signatures across 32 human diseases, revealing disease-specific perturbations, temporal changes, and the impact of smoking on proteostasis.

The paper uses LiP-MS to show that chaperone dependency during in vitro refolding does not correlate with chaperone dependency during in vivo primary protein biogenesis.

This study identifies cpSRP43 as a thermo-switchable chaperone that coordinates light harvesting complex biogenesis by switching between closed and open states to support LHCP biogenesis and protect Chl biosynthesis enzymes.

The paper maps the proteostasis network of membraneless organelles, revealing the role of anabolic components and molecular chaperones in regulating protein conformations.

The paper identifies a novel multi-cochaperone complex involving GR, p23, FKBP51, and Hsp90 using site-specific in-cell photocrosslinking, revealing functional differences between FKBP51 and FKBP52.

This study shows that both structural changes and cellular environments contribute to differences in protein thermostability between two yeast species.

This study uses molecular dynamics simulations to identify key residues and structural features contributing to lid closure in Hsp90's N-terminal domain.

This study investigates the role of the GF-linker in DNAJB chaperones, showing its involvement in autoinhibition and its interaction with Hsc70.

The paper identifies a heat-induced negative feedback loop in Chlamydia involving HagF and HrcA that modulates chaperone gene expression and promotes infectious elementary body formation under stress.

This study uses cryo-EM and biochemistry to show how disease-causing mutations in Gβ5 disrupt its folding by CCT, leading to trapped intermediates and neurological disease.

This study demonstrates that Hsp90 presents the glucocorticoid receptor to the CHIP E3 ubiquitin ligase for degradation during its folding cycle.

This study identifies Siglec-E and LOX-1 as receptors mediating extracellular Hsp70's inflammatory properties through their interaction on dendritic cells.

This study investigates how J-domain proteins induce conformational changes in Hsp70 to activate ATP hydrolysis through free energy simulations and network analysis.

The paper investigates how protein and glutamine biosynthesis inhibitors affect light-induced dephosphorylation and activation of the SBiP1 chaperone in Symbiodinium microadriaticum.

This study identifies AtDjB3 as a critical modulator of the heat shock response in Arabidopsis, showing it enhances thermotolerance by facilitating Hsc70-1 recruitment to protein aggregates and promoting Hsf activation.