Celiac Disease Research and Management

Dietary Exposure to Purified Gliadins and Avenins: Effects on Intestinal and Immune Responses in BALB/c Mice

This study evaluates the effects of dietary gliadin and avenin on intestinal and immune responses in mice, finding differential impacts on villus length, IgG responses, and proteomic profiles.

The immunogenic 33-mer gliadin peptide attenuates flagellin-induced TLR5/NF-κB signaling

The paper investigates how 33-mer gliadin nanostructures affect TLR5/NF-κB signaling in Caco-2 cells, showing they inhibit flagellin-induced activation.

Role of gut epithelial-cell derived transglutaminase 2 in the formation of celiac disease autoantibodies

The paper shows that IEC-derived TG2-DGP fusion protein drives anti-TG2 autoantibody production in celiac disease.

Single-cell multi-omics maps clonal IEL expansion and epithelial remodelling in refractory coeliac disease

This study identifies clonal IEL expansion and epithelial remodelling in RCD1 using single-cell multi-omics, showing distinct immune and epithelial states compared to ACD.

Autologous biopsy-derived co-culture platform for interrogation of intestinal epithelial-T cell crosstalk

This paper develops an autologous co-culture system to study human intestinal IEL-epithelial interactions, showing both non-destructive and cytotoxic responses under different conditions.

A predisposing effect of HLA class II genes in celiac disease by skewing the naive CD4+ T-cell receptor repertoire

The paper shows HLA-DQ2.5 variants increase frequencies of TCR genes involved in gluten epitope recognition in CeD patients, linking HLA to disease by shaping the naive TCR repertoire.

Enterovirus-driven interferon signaling induces epithelial TG2 via JAK-STAT: Implications for the onset of celiac disease

This study shows that enterovirus infection induces TG2 via JAK-STAT signaling in intestinal epithelial cells, linking viral infection to celiac disease onset.

Celiac Disease Risk Allele Frequencies in San Luis (Argentina) and Evaluation of a Saliva Direct PCR Genotyping Approach

The paper evaluates HLA-DQ2.5 and DQ8 allele frequencies in celiac patients and a general population from San Luis, Argentina, and assesses a saliva direct PCR genotyping method for large-scale testing.

CLONAL LYMPHOCYTE EXPANSIONS AND JAK-STAT PATHWAY MUTATIONS DEFINE A PATHOGENIC CONTINUUM DRIVING RESISTANCE TO GLUTEN-FREE DIET IN CELIAC DISEASE

This study identifies clonal lymphocyte expansions and JAK-STAT mutations in celiac disease subtypes, revealing shared mechanisms and limitations of JAK inhibitor therapy.

Celiac disease patient derived iPSC small intestinal epithelial cells are more persistent under cytokine stimuli than healthy control cells

The paper compares the response of celiac disease and healthy control iPSC-derived small intestinal epithelial cells to cytokine stimuli, finding attenuated responses in celiac disease cells.

Spatial Rewiring of Enterocyte Identity in Celiac Disease

This study uses spatial and single-cell transcriptomics to show that celiac disease alters enterocyte states by promoting aberrant zonal co-expression and metaplastic cells.

T Cell Receptors for Antigen on Intraepitheial Cytolytic T Lymphocytes in Celiac Disease Engage Enterocyte HLA-E and HLA-B

This study identifies IFNγ-producing intraepithelial CTLs in celiac disease that interact with HLA-E/B on enterocytes, promoting CTL recruitment and epithelial killing.

Shared TCRs in peripheral blood offer robust celiac disease classification independent of gluten Intake

The paper identifies CeD-specific TCRs in peripheral blood that classify celiac disease independently of gluten intake, showing higher predictive power than traditional TCRs.

Targeting redox imbalance through Nrf2 activation in the inflamed coeliac duodenum.

This study uses single-cell transcriptomics to show redox imbalance in coeliac duodenum, with decreased Nrf2 activation in key cell types, and demonstrates that Nrf2 activation reduces inflammation.

Gut microbiome-derived prolyl peptidases from Segatella copri and Stenotrophomonas maltophilia degrade immunogenic gliadin peptides and restore intestinal barrier integrity in a Celiac disease model

A dendritic cell population responsible for transglutaminase 2-mediated gluten antigen presentation in celiac disease

This study identifies intestinal CD103+ dendritic cells as key players in TG2-mediated gluten antigen presentation in celiac disease and shows their role in activating T cells and upregulating TG2 activity.

Immune signaling mediates stromal changes to support epithelial reprogramming in Celiac duodenum

This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.

Functional immune profiling reveals CD4+ T cell dysregulation associated with celiac disease

The paper uses a novel assay and mathematical model to show CD4+ T cells from celiac disease patients have reduced proliferation and altered cytokine secretion compared to healthy donors.

Microbiota Modulation Induces Elevated Duodenal Eosinophils Upon Gluten Exposure in Mice: Implications for Non-Coeliac Gluten Sensitivity

This study shows that antibiotic-induced microbiome modulation in mice alters immune responses to gluten, increasing duodenal eosinophils and activating epithelial γδ T-cells.

Investigating intestinal epithelium metabolic dysfunction in Celiac Disease using personalized genome scale models

The paper constructs personalized genome-scale models of sIEC metabolism in CeD to identify metabolic dysfunctions and potential therapeutic drugs.

Genome-wide association study identifies novel risk variants for celiac disease in the 5p15.33 locus: insights from a population-based screening of adults, the HUNT study.

This study identifies 13 novel genetic associations for celiac disease, with the 5p15.33 locus showing strong potential, and links IRX1 to rheumatoid arthritis.

One year of gluten free diet impacts gut function and microbiome in celiac disease

This study examines the effects of a one-year gluten-free diet on gut function and microbiome in celiac disease patients compared to healthy volunteers.

Saliva direct PCR protocol for HLA-DQB1*02 genotyping

The paper develops a saliva direct PCR protocol for HLA-DQB1*02 genotyping, enabling detection of the allele without DNA purification.

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

The paper identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease by systematically prioritizing candidate genes in disease loci using multiple computational methods.

Improved HLA-based prediction of coeliac disease identifies two novel HLA risk modifiers, DQ6.2 and DQ7.3

The paper improves HLA-based prediction of coeliac disease by identifying two novel risk modifiers, DQ6.2 and DQ7.3, and develops a new risk score with better predictive performance.

Predictive and Aetiological Potential of Polygenic Strata with Extreme and Moderate Disease Risks Predictions: Case Study of Coeliac Disease GWAS

The paper demonstrates how genomic risk scores can improve diagnostic efficiency for coeliac disease by prioritizing high-risk patients for confirmatory testing.

Persistent alterations in plasma lipid profiles prior to introduction of gluten in the diet associate with progression to celiac disease

The paper identifies lipid profile changes in children before gluten introduction that associate with progression to celiac disease.