interferon and immune responses

This study shows OASL modulates OXA-induced immunogenic cell death in gastric cancer via the cGAS-STING pathway, enhancing chemosensitivity.

This paper identifies a manganese-induced ATM-TBK1 phosphorylation pathway that enhances antiviral immunity by promoting cytokine production and suppressing HIV replication.

The paper shows that transposable element derepression triggers IFN-I signaling, boosting stem/progenitor cell activity after irradiation.

The paper identifies a potent human cGAS inhibitor through high-throughput screening and SAR analysis, showing sub-micromolar activity and partial inhibition of cGAMP levels.

This paper identifies GBP5 as an ISG that inhibits viral replication by blocking N-glycosylation of viral proteins, including SARS-CoV-2 spike, through interaction with the OST complex.

This study identifies ancient immune convergence between prokaryotes and primates through SAMD9/9L proteins and reveals recent adaptations in bonobos and chimps enhancing HIV resistance.

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

The paper shows mammalian ZAP and KHNYN can restrict CpG-enriched avian viruses, with human ZAP or KHNYN independently limiting CpG-enriched IAV in chicken and human cells.

The paper shows IFIT1 genes evolve rapidly across mammals and exhibit varying antiviral activities against viruses like VEEV.

The paper identifies lipid metabolic pathway inhibitors that modulate STING signaling and IFN induction in mouse and human cells.

This study shows that transient skin inflammation activates hematopoietic stem/progenitor cells via type I interferon, altering systemic immunity and affecting atherosclerosis and influenza outcomes.

This study investigates how heme oxygenase-1 (HO1) affects interferon-stimulated gene (ISG) expression in response to various stressors, finding that TNF is a key inducer and HO1 influences nuclear retention of inflammatory transcription factors.

This study challenges previous findings by showing that PEP and its variant do not promote IFN-I production in myeloid cells, suggesting factors independent of PEP regulate this process.

This study reinstates RIG-I and RNF135 in chickens to investigate their role in avian influenza response, finding that their expression exacerbates inflammation and mortality without affecting viral replication.

This study shows human MX1 restricts influenza A virus by sequestering vRNPs in cytoplasmic clusters via dynein and microtubules, reducing viral production.

This study shows that plasmacytoid dendritic cells (pDCs) and their interferons are dispensable or harmful in systemic and respiratory viral infections in mice.

The paper identifies 7-deazapurine protein conjugation as essential for type IV CBASS immunity, revealing the roles of Cap9 and Cap10 in this process.

This study shows that cGAS deficiency in mice promotes tumor growth by supporting B cell persistence and angiogenesis, leading to a pro-tumor immune environment.

The paper investigates how MDA5 CARDs assemble and interact with LGP2 through one-dimensional movement along dsRNA to regulate immune response.

The paper shows that STING activation in myeloid cells leads to paracrine factors that upregulate CCL22 in cancer cells, and that type I interferons also induce CCL22 via a STING-dependent mechanism.

This study shows that PTEN loss in cancer cells activates intrinsic interferon signaling, leading to immune resistance and vulnerability to CDK12 inhibition.

This paper identifies the activation of the BTK-DDX41-STING signaling pathway during CMV lytic infection and shows how the virus subverts this pathway by reducing DDX41 activity.

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

This paper identifies the SKI complex as a broad-spectrum antiviral target, showing that UMB18 increases cellular cholesterol via the mevalonate pathway to inhibit viral replication.

The paper introduces CRITR-seq, a CRISPR-based method to measure transcriptional effects, and identifies NELF as a regulator of influenza transcription and interferon response.

This study identifies PRRSV's Nsp5 protein as a mechanism to inhibit the cGAS-STING-IFN antiviral pathway by blocking STING translocation and activation, thereby promoting viral replication.

This study shows that CsA treatment sequesters IFITM proteins into intraluminal vesicles of late endosomes, reducing their antiviral activity by preventing viral fusion with the limiting membrane of these compartments.

This study identifies an alternative splicing mechanism in IRF7 that generates a protein isoform with enhanced transcriptional activity, leading to increased resistance to viral infection.

The paper identifies DUX4-stimulated genes as an antiviral defense program in human trophoblasts, specifically targeting herpesviruses through an alternative pathway to the IFN response.

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.