Nuclear Structure and Function

This study models lamin aggregation and dissociation in progeria using polymer chains to show how molecular interactions and concentration affect nuclear lamina structure and stability.

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

The paper demonstrates that nuclear envelope budding facilitates the export of large muscle-specific transcripts during myotube formation, involving UIF and ESCRT-III machinery.

The paper shows telomeres initiate nuclear envelope reassembly during mitosis, ensuring proper chromosome encapsulation and preventing micronuclei formation.

This study identifies SRSF1 as a pH-regulating factor that maintains nucleolar integrity by alkalizing the nucleolar microenvironment through its RS domain.

This study shows that nuclear pore complexes dilate during cell differentiation and that Nup133 deficiency prevents this dilation, leading to nuclear envelope instability.

This study shows that RG repeats in C. elegans can accumulate in nucleoli but not form specific sub-nucleolar compartments.

This study investigates how lamins and nesprins influence gene expression through chromatin conformation changes using RNA-seq and live imaging techniques.

The paper identifies a novel phosphorylated NES in Pho4 recognized by Msn5, revealing a phosphate-specific nuclear export mechanism in yeast.

The paper identifies molecular determinants enabling HIV capsid passage through NPCs by analyzing surface amino acid composition and FG repeat interactions.

This study investigates how O-GlcNAc modifications influence lamin A tail processing and identifies a potential link between glucose metabolism and lamina biogenesis.

This study shows that self-assembly is essential for the nuclear membrane recruitment of Drp6, a nuclear dynamin-related protein, independent of its membrane binding ability.

This study identifies Ankle2 as a regulatory subunit of PP2A that promotes BAF dephosphorylation and nuclear reassembly by interacting with Vap33 during telophase.

A whole genome multiparametric CRISPR screen in progeria identifies new pathways that can reverse cellular aging phenotypes by targeting protein translation and related processes.

This study investigates the roles of Ki-67, GNL2, and MDN1 in ribosome biogenesis and transcriptome regulation in HEK293T neuronal lineage cells, revealing their impact on nucleolar function, pre-60S particle export, and neuronal development.

This study shows that an inhomogeneous nuclear pore complex with varying FG-Nup lengths enhances selectivity for karyopherin-bound cargo transport.

The paper uses expansion microscopy and proximity labeling to reveal an asymmetric nuclear pore structure in trypanosomes, identifying unique and conserved components involved in mRNA export.

This study uses GSEA to examine how LBR knockdown affects differentiation and phenotypic differences in HL-60 cell lines, finding changes in heterochromatin, ribosome proteins, and nucleolar structure.

The paper investigates how nuclear blebs alter chromatin packing domains, finding fragmentation of nanoscopic heterochromatin domains within blebs.

This study identifies PMLII as forming biomolecular condensates at sites of nuclear envelope disruption, suggesting a role in stabilizing the site for repair.

This study identifies the sequence specificity of Mcm3's NLS using mutagenesis and AlphaFold 3, showing that precise basic residue positioning is critical for nuclear import and chromatin loading.

This study investigates how HIV-1 capsids pass through nuclear pores, finding that capsids retain their structure and cause NPC scaffold rings to crack.

This study shows elevated SUN1 disrupts cell polarity by coupling microtubules to the nuclear lamina, affecting mechanical force transmission during aging.

This study identifies 174 arsenic-binding proteins in yeast, showing that arsenic disrupts nucleocytoplasmic transport by causing mislocalization and aggregation of nuclear transport factors.

The paper examines emerin expression in breast cancer subtypes and finds it is reduced in aggressive subtypes, correlating with advanced stage, higher proliferation, and receptor-negative status.

The paper identifies two nuclear localization signals in the Anelloviridae capsid protein ORF1, showing their distinct roles in subcellular localization and evolutionary adaptation.

The paper quantifies the lamin A/C distribution during cell migration and aspiration through constrictions, showing the lamin network passively responds to nuclear squeezing.

The paper uses NEED-seq to show lamin B1 and B2 associate with distinct heterochromatin states and are linked to neuronal development.

This study shows that Dictyostelium discoideum uses nuclear pores as conduits for fluid flow during osmotic stress, distinct from passive diffusion and active transport.

The paper identifies three distinct LAD classes based on histone modification patterns in mouse MEF cells, revealing heterochromatin-specific regulatory roles.