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Multi-material delivery strategies to create deferoxamine-functionalized collagen scaffolds for craniofacial bone repair

This paper develops a multi-material scaffold combining deferoxamine with collagen and gelatin to enhance angiogenic-osteogenic coupling for craniofacial bone repair.

Decoupled Surface Engineering Enables Cell-Interactive Edible Microcarriers across Food-Grade Polysaccharides

This paper develops a surface-engineering strategy for edible microcarriers that enhances cell adhesion without limiting material choice, showing improved cell attachment on multiple polysaccharides and cell types.

Broad-spectrum in situ genetic reprogramming of native microbiomes

The paper develops SPARTA for in situ genetic reprogramming of native microbiomes and introduces ScRibe-seq to identify engineered taxa, demonstrating functionality across diverse environments.

A shared wireless acquisition core for cortical and peripheral recordings in freely moving mice

This paper introduces a wireless headstage for simultaneous cortical, muscle, and movement recordings in freely moving mice, demonstrating its utility in seizure detection and behavior-related neural activity analysis.

Engineered microvessel networks -- Longitudinal transcriptomic profiling validates chip-grown tissues as a robust model for studying vasculature

The paper validates chip-grown vascular tissues as a model for studying vasculature by showing cell provenance affects network formation and transcriptomic profiles.

Agile manufacturing of PDMS microfluidic devices for cell culture without a clean room

This paper describes a method to fabricate PDMS microfluidic devices using laser-cut master molds, enabling rapid and cost-effective prototyping without a clean room.

Benchmarking foundation models for resting-state functional magnetic resonance imaging time series in cognitive aging research

This study benchmarks foundation models for resting-state fMRI time series in cognitive aging, finding mixed results on their utility for cognitive assessment and prediction.

An Accessible and Scalable Pipette-Driven Microfluidic Platform for Lipid Nanoparticle Formulation

This paper introduces a microfluidic platform for lipid nanoparticle formulation that improves scalability and efficiency in mRNA delivery.

Receptor-guided engineering of oncolytic vaccinia creates a synthetic support niche for off-the-shelf NK cell therapy

This paper develops a framework to engineer oncolytic vaccinia virus to support off-the-shelf NK cells by aligning viral payloads with NK cell manufacturing limitations.

Tissue-like Viscoelasticity Drives Muscle Stem Cell Expansion Through Mechanical Memory Formation

This study shows that tissue-like viscoelastic substrates enhance muscle stem cell expansion by creating mechanical memory through focal adhesion stabilization and Rac-Akt signaling.

PROST: An Open Toolbox, Harmonised Multi-Lab Dataset, and Meta-Analysis of Ankle-Foot Roll-Over Shape

This paper develops a harmonized multi-lab dataset and analysis tool for ankle-foot roll-over shape, finding that ROS geometry is participant-specific and not predicted by anthropometrics.

Distinct mechanical signatures of dairy and plant-based cheeses

The paper compares the mechanical properties of dairy and plant-based cheeses using various tests and consumer feedback, finding significant differences in texture and consumer preference.

A Continuum Fibre Network Model for the Anisotropic and Compressible Mechanics of Human Skin

This paper develops a Continuum Fibre Network model to simulate anisotropic and compressible mechanics of human skin using experimental data.

Multimodal imaging links molecular identity with nanoscale-resolved 3D cell morphology in opossum cortical cultures

This paper uses multimodal imaging to link molecular identity with nanoscale 3D cell morphology in opossum cortical cultures, showing how molecular changes correlate with morphological differences during development.

Synergy-informed bilevel optimization reveals joint-specific benefits for realistic exoskeleton torque prediction

This study uses synergy-informed bilevel optimization to improve exoskeleton torque prediction by preventing non-physiological muscle shutdown, showing better alignment with experimental data.

Mitochondrial transplantation redirects rather than suppresses the inflammatory response in primary human monocytes

This study transplants mitochondria into human monocytes, altering their inflammatory response by reducing pro-inflammatory mediators and increasing IL-10.

Generative design of de novo AAV vectors with unique serological profiles

This paper designs de novo AAV vectors with unique serological profiles using a variational autoencoder, achieving transduction efficiency and nAb avoidance in human sera.

Citrate-Based Hydrogels Promote Closure of Infected Diabetic Wounds

This study evaluates citrate-based hydrogels for promoting wound closure in infected diabetic wounds, finding that formulations with copper nanoparticles and cell adhesion peptides significantly improve healing.

Preserving Nanotherapy-Induced Allogeneic Murine Islet Graft Tolerance During Distal Methicillin-Resistant Staphylococcus aureus Skin Infection

This study shows that a nanotherapy (rPS) that induces islet graft tolerance can be compromised by MRSA infection, but combining it with methylprednisolone improves survival.

From Fill to Freeze: Redesigning homeRNA to Enable Robust Sampling and Scalable Downstream Processing Workflows for Remote Blood Transcriptomics

This paper validates the redesigned homeRNA platform's robustness to remote study stresses, showing it maintains RNA quality under varied conditions and storage times.