M. Cheng

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans

The paper identifies host genetic factors influencing anti-PD-1 response in mice and humans by mapping QTLs and finding a core gene network with prognostic value in human tumors.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Development of a LRRC15-Targeted Radio-Immunotheranostic Approach to Deplete Pro-tumorigenic Mechanisms and Immunotherapy Resistance

This paper develops a radio-theranostic approach targeting LRRC15 to image and treat cancer, showing tumor reduction and reversal of immunotherapy resistance.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

In vivo selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord

The paper identifies superior AAV capsids for targeted spinal cord gene therapy in non-human primates through in vivo selection and evaluates their biodistribution and expression.

Machine learning general transcriptional predictors of plant disease

This study uses machine learning to predict plant disease development across diverse pathogens by analyzing early transcriptional responses, identifying novel genes involved in a general immune response.

Rapid and visual detection of Schistosoma japonicum circulating nucleic acids by CRISPR-Cas12a

This paper develops a CRISPR-Cas12a-based method for detecting Schistosoma japonicum circulating nucleic acids with high sensitivity and specificity, validated using rabbit serum samples.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

HDL-C as a potential medium between depletion of Lachnospiraceae genera and hypertension under high-calorie diet

This study links gut microbial depletion of Lachnospiraceae genera to lower HDL-C and hypertension in a high-calorie diet population, suggesting HDL-C as a mediator.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

Population Transcriptome and Phenotype Reveal that Rht-D1b Contributes a Larger Seedling Root to Modern Bread Wheat

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

A Genomically and Clinically Annotated Patient Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer

The paper describes a collection of 79 genomically and clinically annotated lung cancer PDX models that retain patient tumor features and treatment responses, available through MMHCdb.

Microbial dysbiosis and metabolic disorders promote rheumatoid arthritis across successive stages: a multi-omics cohort study

This study identifies stage-specific microbial and metabolic changes in RA progression using multi-omics data from a cohort of patients.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

An Engineered Genetic Circuit for Lactose Intolerance Alleviation Coupled with Gut Microbiota Recovery

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

A single nonsynonymous mutation on gene encoding E protein of Zika virus leads to increased neurovirulence in vivo

Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by PhIP-Seq

This study uses PhIP-Seq to identify novel autoantigens in APS1, linking specific autoantibodies to clinical phenotypes like ovarian insufficiency and intestinal dysfunction.

Combining Focal-ERG, Fluorescein Angiography, and SD-OCT for Retinal Neurovascular Analysis in a Mouse OIR-Model.

The paper combines FA, SD-OCT, and focal-ERG to analyze retinal structure-function relationships in a mouse OIR model, showing non-uniform retinal damage and enabling longitudinal tracking of treated and untreated zones.

CASLFA: CRISPR/Cas9-mediated lateral flow nucleic acid assay

CASLFA enables rapid, specific detection of pathogens and GMOs with high sensitivity and no technical expertise.

Universal and naked-eye gene detection platform based on CRISPR/Cas12a/13a system

This paper develops a CRISPR-based colorimetric gene detection platform using AuNPs that enables naked-eye detection of DNA and RNA targets with high sensitivity and universality.

Rare non-synonymous germline mutations systematically define the risk of triple negative breast cancer

This paper identifies rare germline mutations associated with triple-negative breast cancer risk using a machine learning approach and shows improved risk prediction compared to existing methods.