Author

A. Castello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

I. Davis· 4 shared M. Garcia-Moreno· 3 shared L. Iselin· 2 shared M. Noerenberg· 2 shared R. M. Parton· 2 shared S. Mohammed· 2 shared W. Kamel· 2 shared A. Andrejeva· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMicrobiology

I. Davis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Copy number variation on ABCC2-DNMBP loci impacts the diversity and composition of the gut microbiota in pigs

Y. Ramayo-Caldas, D. Crespo-Piazuelo, J. Morata, O. Gonzalez-Rodriguez, C. Sebastia, A. Castello, A. Dalmau, S. E. Ramos-Onsins, K. Alexiou, J. M. Folch, R. Quintanilla, M. Ballester

This study identifies a copy number variant (CNV) in the ABCC2-DNMBP locus that influences gut microbiota diversity and composition in pigs.

bioRxiv · Oct 6, 2022 · PreprintMicrobiology

Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

W. Kamel, V. Ruscica, A. Embarc-Buh, Z. R. de Laurent, M. Garcia-Moreno, Y. Demyanenko, M. Madhusudhan, L. Iselin, A. Järvelin, M. Hannan, E. Kitano, S. Moore, A. Merits, I. Davis, S. Mohammed, A. Castello

This study identifies nuclear RNA-binding proteins that are translocated to the cytoplasm during alphavirus infection and exhibit antiviral activity.

bioRxiv · Oct 6, 2021Microbiology

Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences

J. Y. Lee, P. A. Wing, D. S. Gala, M. Noerenberg, A. I. Jarvelin, J. Titlow, X. Zhuang, N. Palmalux, L. Iselin, M. K. Thompson, R. M. Parton, A. Wainman, D. Agranoff, W. James, A. Castello, , I. Davis

The paper quantifies SARS-CoV-2 RNA molecules using smFISH, revealing genomic RNA stability, cell-to-cell replication variability, and slower replication kinetics for the B.1.1.7 variant compared to the Victoria strain.

bioRxiv · Jun 29, 2021Microbiology

Global analysis of protein-RNA interactions in SARS-CoV-2 infected cells reveals key regulators of infection

W. Kamel, M. Noerenberg, B. Cerikan, H. Chen, A. I. Järvelin, M. Kammoun, J. Lee, N. Shuai, M. Garcia-Moreno, A. Andrejeva, M. J. Deery, C. J. Neufeldt, M. Cortese, M. L. Knight, K. S. Lilley, , A. Castello

The paper identifies key host and viral RNA-binding proteins involved in SARS-CoV-2 infection and shows that drugs targeting these proteins can inhibit infection.

bioRxiv · Nov 25, 2020Microbiology

CryoSIM: super resolution 3D structured illumination cryogenic fluorescence microscopy for correlated ultra-structural imaging

M. A. Phillips, M. Harkiolaki, D. M. S. Pinto, R. M. Parton, A. Palanca, M. Garcia-Moreno, I. Kounatidis, J. Sedat, D. I. Stuart, A. Castello, M. J. Booth, I. Davis, I. M. Dobbie

The paper introduces cryoSIM, a super-resolution 3D fluorescence microscope for cryo-imaging that can be replicated with off-the-shelf components and open-source software.

bioRxiv · Mar 9, 2020Cell Biology