M. A. Phillips

Rubisco supplies pyruvate for the 2-C-methyl-D-erythritol-4-phosphate pathway

The paper shows rubisco produces pyruvate for isoprenoid and fatty acid biosynthesis, resolving the pyruvate paradox and linking the MEP pathway to carbon assimilation.

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL)

This paper identifies (S)-SW228703, a tyrosine amide with fast-killing antimalarial activity against blood and liver stages of Plasmodium falciparum, and links resistance to mutations in PfCARL and PfACT.

Building bridges from genome to physiology using machine learning and Drosophila experimental evolution

The paper uses machine learning and Drosophila experimental evolution to identify genomic regions causally linked to physiological traits.

Strength of selection potentiates distinct adaptive responses in an evolution experiment with outcrossing yeast

This study examines how varying ethanol stress levels affect genetic adaptation in yeast, finding that stronger selection leads to greater allele frequency changes and distinct genomic responses.

Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and function

The paper constructs an orthologous gene coevolution network from 332 budding yeast species to explore eukaryotic cellular and genomic structure and function, revealing insights into gene connectivity and environmental fitness.

Examination of gene loss in the DNA mismatch repair pathway and its mutational consequences in a fungal phylum

The paper examines gene loss in the DNA mismatch repair pathway across fungal species, finding extensive MMR gene loss in powdery mildew lineages associated with increased mutation rates.

Python-Microscope: A new open source Python library for the control of microscopes

Python-Microscope provides a scalable, open-source Python library for controlling complex custom microscopes and simulating microscope systems.

Microscope-Cockpit: Python-based bespoke microscopy for bio-medical science

The paper introduces Microscope-Cockpit, a Python-based GUI for controlling bespoke microscopes, enabling efficient specimen navigation and hardware integration through open-source tools.

Genome-Wide Architecture of Adaptation in Experimentally Evolved Drosophila

This study uses experimentally evolved Drosophila populations and statistical learning to show that both genome and transcriptome data can predict phenotypes, with widespread pleiotropy observed.

Wavefront-sensorless adaptive optics with a laser-free spinning disk confocal microscope

The paper introduces wavefront-sensorless adaptive optics for a laser-free spinning disk confocal microscope, improving signal, contrast, and resolution by correcting specimen-induced aberrations.

CryoSIM: super resolution 3D structured illumination cryogenic fluorescence microscopy for correlated ultra-structural imaging

The paper introduces cryoSIM, a super-resolution 3D fluorescence microscope for cryo-imaging that can be replicated with off-the-shelf components and open-source software.

Correlative cryo-structured illumination fluorescence microscopy and soft X-ray tomography elucidates reovirus intracellular release pathway

This study develops a correlative imaging platform combining cryo-SIM and SXT to study reovirus release from intracellular vesicles, revealing novel virus-induced structures.

IsoSense: frequency enhanced sensorless adaptive optics through structured illumination

IsoSense improves sensorless adaptive optics by using structured illumination to enhance spatial frequencies for reliable wavefront sensing in microscopy.