S. Xiang

Multivalent 28S rRNA Is the Organizer of the Nucleolus's Multi-layered Architecture

This study identifies 28S rRNA as a key organizer of the tripartite nucleolus structure through multivalent interactions that drive the formation of the three-layered architecture.

The roles of DDR2 and substrate stiffness on cancer cell transcriptome and proliferation

This study investigates how DDR2 and substrate stiffness affect cancer cell proliferation and transcriptome, revealing distinct regulatory mechanisms.

Structural insights into Rad18 targeting by the SLF1 BRCT domains

The paper presents the crystal structure of SLF1tBRCT bound to Rad18 peptide, revealing mechanisms of Rad18 recognition and BRCT-mediated complex assembly.

Structural basis for the Rad6 activation by the Bre1 N-terminal domain

The paper presents the crystal structure of the Bre1 RBD-Rad6 complex and shows how their interaction activates Rad6 for H2Bub1 catalysis.

Manipulating Oxalate Decarboxylase Provides the Basis of Antilithic Therapy by Acting on the Gut Microbiota

The paper identifies Zn2+ as a therapeutic agent for calcium oxalate kidney stones by enhancing oxalate-degrading bacteria and their enzymes in the gut microbiota.

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

In Vitro Activities of Daptomycin Combined with Fosfomycin or Rifampin on Planktonic and Adherent Linezolid-resistant Enterococcus faecalis

This study evaluates the effectiveness of daptomycin combined with fosfomycin or rifampin against linezolid-resistant Enterococcus faecalis biofilms and planktonic cells.