A. Jose

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

Identification of Mitosis Stages Using Artificial Neural Networks for 3D Time Lapse Cell Sequences

This study uses 3D CNN models to classify mitosis stages in 3D time-lapse cell sequences, achieving higher accuracy than previous methods.

CELL CYCLE STATE PREDICTION USING GRAPH NEURAL NETWORKS

The paper predicts mitosis stages using a CNN followed by a GNN, incorporating timestamps as a graph to model internal interactions, achieving performance comparable to state-of-the-art methods.

Insights into cargo sorting by SNX32 in neuronal and non-neuronal cells: physiological implications in neurite outgrowth

This study identifies SNX32's role in cargo sorting via its PX and BAR domains, showing its involvement in transferrin trafficking and neuronal differentiation.

Phosphotungstic acid (PTA) preferentially binds to collagen-rich regions of porcine carotid arteries and human atherosclerotic plaques using 3D micro-computed tomography (CE-μCT)

This paper demonstrates that phosphotungstic acid (PTA) binds preferentially to collagen-rich regions in porcine carotid arteries and human atherosclerotic plaques, enabling non-destructive collagen quantification via 3D micro-CT.

Modulation of the gut microbiome by novel synthetic glycans for the production of propionate and the reduction of cardiometabolic risk factors

This paper identifies a synthetic glycan, KB39, that increases propionate production by the gut microbiome and reduces cardiometabolic risk factors in mice.