Author

F. Borriello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

I. Zanoni· 5 shared D. J. Dowling· 3 shared E. Nanishi· 3 shared O. Levy· 3 shared Y. Saito· 3 shared A. Chang· 2 shared A. G. Schmidt· 2 shared A. Ozonoff· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

I. Zanoni

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6 papers

Recent·Most cited

Correction of age-associated defects in dendritic cell functions enables CD4+ T cells to eradicate tumors in the elderly

D. Zhivaki, F. Borriello, S. Kennedy, C. L. Evavold, K. M. Bahleda, K. L. Chapman, I. Zanoni, J. C. Kagan

This study shows that CD4+ T cells, supported by hyperactivator-stimulated dendritic cells, can eliminate tumors in elderly mice, suggesting a strategy to correct age-related immune defects.

bioRxiv · Nov 8, 2022 · PreprintImmunology

Shaping neonatal immunization by tuning delivery of synergistic adjuvants via nanocarriers

S. Barman, F. Borriello, B. Brook, C. Pietrasanta, M. De Leon, C. Sweitzer, M. Menon, S. D. van Haren, D. Soni, Y. Saito, E. Nanishi, S. Yi, S. Bobbala, O. Levy, E. A. Scott, D. J. Dowling

This study identifies synergistic adjuvants for neonatal immunization using nanocarriers, showing enhanced Th1 bias and humoral responses in mice.

bioRxiv · Jun 3, 2022Immunology

Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages

R. G. Huffman, A. Leduc, C. Wichmann, M. di Gioia, F. Borriello, H. Specht, J. Derks, S. Khan, L. Khoury, E. Emmott, A. A. Petelski, D. H. Perlman, J. Cox, I. Zanoni, N. Slavov

The paper introduces pSCoPE, a single-cell proteomics method that improves sensitivity, completeness, and depth, enabling analysis of protein variation in macrophages.

bioRxiv · Mar 16, 2022Immunology

An adjuvanted SARS-CoV-2 RBD nanoparticle elicits neutralizing antibodies and fully protective immunity in aged mice

F. Borriello, E. Nanishi, H.-S. Seo, T. R. OMeara, M. E. McGrath, Y. Saito, R. E. Haupt, J. Chen, J. Diray-Arce, K. Song, A. Z. Xu, T. M. Caradonna, J. Feldman, B. M. Hauser, A. G. Schmidt, , O. Levy

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

bioRxiv · Sep 9, 2021 · PreprintImmunology

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

bioRxiv · May 20, 2021Immunology

The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity

F. Borriello, R. Spreafico, V. Poli, J. Chou, N. Barrett, L. Lacanfora, M. Franco, L. Marongiu, Y. Iwakura, F. Pucci, M. Kruppa, Z. Ma, D. Williams, I. Zanoni

This study shows that soluble fungal polysaccharides are immunosilent in peripheral tissues but become potent immunogens in draining lymph nodes without requiring dendritic cell migration.

bioRxiv · Mar 3, 2020 · PreprintImmunology