M. Schindler

CD4+ T cells facilitate replication of primary HIV-1 strains in macrophages and formation of macrophage internal virus-containing compartments.

This study shows that non-infected CD4+ T cells enhance replication of primary HIV-1 in macrophages and promote formation of virus-containing compartments (VCCs).

Nifurpirinol: A potent inducer of FSGS-like glomerular injury in transgenic zebrafish

This study introduces Nifurpirinol as a more efficient prodrug for inducing FSGS-like glomerular injury in zebrafish larvae, suitable for high-content drug screening.

CD81 represses NF-?B in HCV-expressing hepatoma cells

This study identifies CD81 as a negative regulator of NF-κB signaling in HCV-expressing hepatoma cells, showing that its downregulation enhances NF-κB activity and promotes cell growth.

Tetherin restricts SARS-CoV-2 replication despite antagonistic effects of Spike and ORF7a

This study shows that SARS-CoV-2 S and ORF7a antagonize Tetherin, but Tetherin still restricts SARS-CoV-2 replication.

Abemaciclib restricts HCMV replication by suppressing pUL97-mediated phosphorylation of SAMHD1

This study shows that Abemaciclib inhibits HCMV replication by blocking pUL97-mediated SAMHD1 phosphorylation, establishing SAMHD1 as a therapeutic target.

Co-option of the transcription factor SALL1 in mole ovotestis formation

The paper identifies SALL1 as a co-opted gene in mole ovotestis formation through comparative epigenetic and transcriptional analyses, showing enhancer evolution drives testicular tissue development.

A broadly neutralizing biparatopic Nanobody protects mice from lethal challenge with SARS-CoV-2 variants of concern

This study identifies a biparatopic nanobody that protects mice from lethal SARS-CoV-2 infection and reduces viral load and inflammation.

Rapid, dose-dependent and efficient inactivation of surface dried SARS-CoV-2 by 254 nm UV-C irradiation

This study evaluates the effectiveness of 254 nm UV-C irradiation in inactivating surface-dried SARS-CoV-2, showing dose-dependent inactivation and a non-linear relationship between UV-C dose and viral titer reduction.

NeutrobodyPlex - Nanobodies to monitor a SARS-CoV-2 neutralizing immune response

The paper develops NeutrobodyPlex, a multiplex assay using bivalent nanobodies to analyze neutralizing antibodies against SARS-CoV-2 in patient sera.

The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus.

The paper identifies HD5(1-9), a defensin-derived peptide, as an inhibitor of HCMV cellular attachment and entry, with low toxicity.

Prolonged podocyte depletion in larval zebrafish resembles mammalian focal and segmental glomerulosclerosis

This study shows that podocyte-depleted zebrafish larvae develop features resembling human focal and segmental glomerulosclerosis, including proteinuria and PEC activation, and can be used for drug screening.

Platelet-neutrophil aggregates promote skin pathology in psoriasis

This study identifies platelet-neutrophil aggregates as contributors to psoriasis skin pathology and disease severity.

Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway

The paper identifies over 200 alternative splicing events regulating protein transport across the secretory pathway using RNA-Seq and genetic perturbations.