A. Patapoutian

This study identifies PIEZO2 as a mechanotransducer in juxtaglomerular cells that regulates renin release and blood pressure.

This study reevaluates Piezo1's role as a gut RNA sensor and finds that fecal ssRNA does not activate Piezo1, supporting its function in mechanosensation.

This study characterizes the mechanosensitive ion channel FLYC1 using cryo-EM, MD simulations, and electrophysiology, revealing structural features and conformational transitions involved in mechano-gating.

The paper identifies a stretch-activated ion channel in touch-sensitive trigger hairs of carnivorous Droseraceae plants, suggesting it evolved from ancestral mechanosensitive channels.

This study shows that PIEZO1 channel localization dynamics regulate keratinocyte migration and wound healing speed in mice.

This study identifies PIEZO as a mechanosensitive ion channel in Arabidopsis roots, showing its role in mechanotransduction and mechanical stress response.

The paper presents the cryo-EM structure of the mechanically activated ion channel OSCA1.2 and supports its role in mechanosensation.

The paper identifies OSCA proteins in plants and their homologues TMEM63 in animals as evolutionarily conserved mechanosensitive ion channels involved in mechanotransduction.

The paper reports the high-resolution cryo-EM structure of human SWELL1, revealing its trimer of dimers assembly and identifying a charged residue critical for pore function in VRAC.

The paper identifies a common Piezo1 variant in African populations that causes xerocytosis and reduces Plasmodium infection.