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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
K. Saotome, L. L. McGoldrick, J.-H. Ho, T. F. Ramlall, S. Shah, M. J. Moore, J. H. Kim, R. Leidich, W. C. Olson, M. C. Franklin
This study uses cryoEM to reveal structural details of CXCR4 activation by CXCL12 and its oligomerization, showing new modes of GPCR regulation.
bioRxiv · Feb 9, 2024Biochemistry
K. Saotome, D. Dudgeon, K. Colotti, M. J. Moore, J. Jones, Y. Zhou, A. Rafique, G. D. Yancopoulos, A. J. Murphy, J. C. Lin, W. C. Olson, M. C. Franklin
The paper reports cryoEM structures of TCR-CD3 complexes and pMHC ligands, revealing structural insights into TCR recognition of cancer antigens.
bioRxiv · Aug 18, 2022Biochemistry
Y. Zhou, P. E. Stevis, J. Cao, K. Saotome, J. Wu, A. G. Zaretsky, S. Haxhinasto, G. D. Yancopoulos, A. J. Murphy, M. W. Sleeman, W. C. Olson, M. C. Franklin
The paper determines cryo-EM structures of gp130 family cytokine signaling complexes to reveal structural insights into their assembly and biological specificity.
bioRxiv · Jun 30, 2022Biochemistry
S. Jojoa-Cruz, K. Saotome, C. C. Tsui, W.-H. Lee, M. S. P. Sansom, S. E. Murthy, A. Patapoutian, A. B. Ward
This study characterizes the mechanosensitive ion channel FLYC1 using cryo-EM, MD simulations, and electrophysiology, revealing structural features and conformational transitions involved in mechano-gating.
bioRxiv · Jun 30, 2021Biochemistry
R. Copin, A. Baum, E. Wloga, K. E. Pascal, S. Giordano, B. O. Fulton, A. Zhou, N. Negron, K. Lanza, N. Chan, A. Coppola, J. Chiu, M. Ni, G. S. Atwal, A. Romero Hernandez, , C. A. Kyratsous
This study shows that REGEN-COV, a combination of non-competing antibodies, provides broad coverage against SARS-CoV-2 variants and prevents the emergence of new variants in clinical and preclinical settings.
bioRxiv · Mar 10, 2021 · PreprintMicrobiology
K. Saotome, B. Teng, C. C. Tsui, W.-H. Lee, Y.-H. Tu, M. S. P. Sansom, E. R. Liman, A. B. Ward
The paper reports cryo-EM structures of zebrafish Otop1 and chicken Otop3, revealing their dimeric architecture and potential proton conduction pathways.
bioRxiv · Feb 6, 2019Biochemistry
S. Jojoa Cruz, K. Saotome, S. E. Murthy, C. C. Tsui, M. S. P. Sansom, A. Patapoutian, A. B. Ward
The paper presents the cryo-EM structure of the mechanically activated ion channel OSCA1.2 and supports its role in mechanosensation.
bioRxiv · Sep 4, 2018Biophysics
J. M. Kefauver, K. Saotome, A. E. Dubin, J. Pallesen, C. A. Cottrell, G. Hong, S. M. Cahalan, Z. Qiu, C. S. Crowley, T. Whitwam, W.-H. Lee, A. B. Ward, A. Patapoutian
The paper reports the high-resolution cryo-EM structure of human SWELL1, revealing its trimer of dimers assembly and identifying a charged residue critical for pore function in VRAC.
bioRxiv · May 16, 2018Biochemistry