C. Feng

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Harnessing Landrace Diversity Empowers Wheat Breeding for Climate Resilience

This study uses landrace diversity in wheat to identify genetic resources for climate resilience and improved traits, providing a framework for crop improvement.

The wheat powdery mildew resistance gene Pm4 also confers resistance to wheat blast

The paper identifies that the wheat resistance gene Pm4 confers resistance to wheat blast caused by Magnaporthe oryzae, highlighting its importance for developing resistant cultivars in affected regions.

Bivalent mRNA vaccine improves antibody-mediated neutralization of many SARS-CoV-2 Omicron lineage variants

This study evaluates the neutralizing antibody response to bivalent mRNA vaccines against multiple Omicron variants, showing enhanced neutralization against BQ.1 and BQ.1.1.

Bacterial Microbiome and Host Inflammatory Gene Expression in Foreskin Tissue

The paper analyzes the foreskin microbiome and host gene expression in adolescents from South Africa and Uganda, finding no treatment effect on bacterial communities but inverse correlations between bacterial abundance and inflammatory gene expression.

Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sites

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

Rotations improve the diversity of rhizosphere soil bacterial communities, enzyme activities and tomato yield

This study shows that rotating tomato with eggplant or arrowhead improves rhizosphere bacterial diversity, enzyme activity, and tomato yield and quality while reducing nitrate content.

Arabidopsis MLO4 Functions as a Ca2+ Channel Essential for Mechanosensing in Root Tips

This study identifies MLO4 as a Ca2+ channel essential for mechanosensing in Arabidopsis root tips, linking touch stimulation to Ca2+ elevation.

CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer

This study uses CRISPR screens to identify genetic factors affecting PARP inhibitor sensitivity and resistance in prostate cancer, revealing novel targets and mechanisms.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

Abundance and expression of hgcAB genes and mercury availability jointly explain methylmercury formation in stratified brackish waters

The paper investigates how hgcA gene abundance and HgII-sulfide concentrations predict methylmercury formation in stratified brackish waters.

High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infection

This study uses high-temporal-resolution transcriptome profiling to compare interferon responses after mRNA vaccination and SARS-CoV-2 infection, identifying distinct signatures linked to immune outcomes.

A magnetic field prevents alcoholic liver disease by reducing oxidative stress

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

Crash landing of Vibrio cholerae by MSHA pili-assisted braking and anchoring in a viscoelastic environment

This study quantifies how Vibrio cholerae lands on surfaces in viscoelastic environments using MSHA pili and flagellum, showing pili act as brakes and anchors during landing.

Colonial choanoflagellate isolated from Mono Lake harbors a microbiome

The paper isolates and characterizes a new colonial choanoflagellate species, Barroeca monosierra, from Mono Lake that hosts a microbiome, offering a model for studying eukaryote-bacteria interactions.

A chloride efflux transporter OsBIRG1 regulates grain size and salt tolerance in rice

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

Potent neutralization antibodies induced by a recombinant trimeric Spike protein vaccine candidate containing PIKA adjuvant for COVID-19

This study evaluates a recombinant trimeric Spike protein vaccine with PIKA adjuvant, showing high neutralizing antibody titers and efficacy against COVID-19.

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in mice

A BCG-adjuvanted vaccine provides sterilizing immunity against SARS-CoV-2 in mice, with high neutralizing antibody titers and Th1 responses.

The Self-Interest of Adolescents Overrules Cooperation in Social Dilemmas

This study finds adolescents cooperate less than adults in social dilemmas due to lower intrinsic reward for reciprocity, not poor expectation of others' cooperation.

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

Transcriptome-Wide Combinatorial RNA Structure Probing in Living Cells

This study introduces icLASER, a method to map RNA solvent accessibility transcriptome-wide, and combines it with icSHAPE to predict RNA-protein interactions and polyadenylation sites.

Marine snow as a habitat for microbial mercury methylators in the Baltic Sea

The paper identifies marine snow as a hotspot for mercury methylators in the Baltic Sea by analyzing metagenomic data from different environmental conditions.

Genetic diversity of the spinach downy mildew pathogen based on hierarchical sampling

The paper analyzes genetic diversity in the spinach downy mildew pathogen Peronospora effusa using SNP loci from 67 isolates, revealing clonal and sexual reproduction strategies and population substructure.

Microbial redox activity mediated anaerobic pyrite oxidation under circumneutral conditions

This study investigates microbial mediation of anaerobic pyrite oxidation under circumneutral conditions and identifies ligand production as a preferred pathway over acidic micro-environments.

An antibody drug conjugate targeting a GSTA glycosite-signature epitope of mucin1 expressed by non-small cell lung cancer

This paper develops an anti-MUC1 antibody-drug conjugate targeting a GSTA glycosite-signature epitope, showing potent antitumoral efficacy and low toxicity in NSCLC models.

Development of SSR markers related to seed storability traits in maize subjected to artificial seed aging conditions

This study develops SSR markers linked to seed storability traits in maize by mapping QTL in two populations and identifies four markers with high selection efficiency.