Author

A. Spencer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Organism:virus· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

T. Lambe· 3 shared A. Flaxman· 2 shared A. M. Bennett· 2 shared C. Bissett· 2 shared C. Gilbride· 2 shared E. Allen· 2 shared H. Sharpe· 2 shared I. Garratt· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

T. Lambe

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Potent immunogenicity and protective efficacy of a multi-pathogen vaccination targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses

A. Flaxman, S. Sebastian, S. Appelberg, K. Cha, M. Ulaszewska, J. Purushotham, C. Gilbride, H. Sharpe, A. Spencer, S. Bibi, D. Wright, S. Dowall, L. Easterbrook, S. Findlay-Wilson, S. Gilbert, , T. Lambe

This paper develops a multi-pathogen vaccine targeting Zaire ebolavirus, Sudan ebolavirus, Marburg and Lassa viruses, showing strong immunogenicity and protective efficacy in animal models.

bioRxiv · Nov 3, 2023 · PreprintImmunology

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

P. Zhang, S. Gilbert, J. Radecke, T. Ni, L. Mendonca, Y. Zhu, A. Howe, P. M. Shah, Y. Sheng, A.-S. Krebs, H. M. E. Duyvesteyn, E. Allen, T. Lambe, C. Bissett, S. Morris, , D. I. Stuart

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

bioRxiv · May 22, 2023Microbiology

The androgen receptor does not directly regulate the transcription of DNA damage response genes

S. Hasterok, T. G. Scott, D. G. Roller, A. Spencer, A. B. Dutta, K. M. Sathyan, D. E. Frigo, M. J. Guertin, D. Gioeli

This study investigates whether the androgen receptor directly regulates DNA damage response gene transcription in prostate cancer cells and finds it does not.

bioRxiv · May 13, 2023Cancer Biology

A Comparison of Persistence of SARS-CoV-2 Variants on Stainless Steel

T. Pottage, I. Garratt, O. Onianwa, A. Spencer, S. E. Paton, J. Dunning, A. M. Bennett

This study compares the persistence of SARS-CoV-2 variants on stainless steel to an established isolate, finding no significant difference in inactivation rates.

bioRxiv · Apr 8, 2021Microbiology

Persistence of SARS-CoV-2 virus and viral RNA on hydrophobic and hydrophilic surfaces and investigating contamination concentration

S. E. Paton, A. Spencer, I. Garratt, K.-A. Thompson, I. Dinesh, P. AranegaBou, D. Stevenson, S. O. Clark, J. Dunning, A. M. Bennett, T. Pottage

This study examines the persistence of SARS-CoV-2 viability and RNA on different surfaces, finding that viability declines faster than RNA stability and is independent of initial concentration.

bioRxiv · Mar 11, 2021 · PreprintMicrobiology

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

N. van Doremalen, T. Lambe, A. Spencer, S. Belij-Rammerstorfer, J. Purushotham, J. Port, V. Avanzato, T. Bushmaker, A. Flaxman, M. Ulaszewska, F. Feldmann, E. Allen, H. Sharpe, J. Schulz, M. Holbrook, , V. Munster

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

bioRxiv · May 13, 2020 · PreprintMicrobiology

Biomechanical Regulation of Breast Cancer Metastasis and Progression

A. Spencer, A. Sligar, D. Chavarria, J. Lee, D. Choksi, N. Patil, H. Lee, A. Veith, W. Riley, S. Desai, A. Abbaspour, R. Singeetham, A. Baker

This study investigates how mechanical forces affect breast cancer cell behavior, finding that tension alters gene expression, increases chemoresistance, and promotes metastasis through specific signaling pathways.

bioRxiv · Jan 21, 2020Cancer Biology