S. Morris

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host

This study shows that memory CD4+ T cell persistence depends on cell age, not host chronological age, using mouse models and mathematical models.

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

Major trends and environmental correlates of spatiotemporal shifts in the distribution of genes compared to a biogeochemical model simulation in the Chesapeake Bay

The paper compares metagenomic and metatranscriptomic data with biogeochemical model predictions to identify discrepancies in microbial gene abundance and function in the Chesapeake Bay.

The two-component system CroRS regulates isoprenoid flux to mediate antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis

This paper identifies the CroRS two-component system as a regulator of isoprenoid biosynthesis in Enterococcus faecalis, linking it to antimicrobial tolerance through cell envelope maintenance.

Different helminth parasites show contrasting relationships with age in a wild ungulate

The paper examines age-related changes in helminth parasite infections in wild red deer, finding contrasting trends between strongyle nematodes and liver fluke/tissue worm infections.

Helminth parasites decrease survival probability in young red deer

This study shows helminth infections reduce survival in young red deer, with strongyles and Fasciola hepatica linked to lower survival in calves and yearlings.

Exposure to the gut microbiota from cigarette smoke-exposed mice exacerbates cigarette smoke extract-induced inflammation in zebrafish larvae

The paper shows that gut microbiota from cigarette smoke-exposed mice worsens inflammation in zebrafish larvae exposed to cigarette smoke extract.

Ageing red deer alter their spatial behaviour and become less social

This study shows that older red deer become less socially connected and alter their spatial behavior, indicating age-related changes in social and spatial dynamics in a wild population.

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studies.

EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes.

Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88-dependent acceleration of hyperlipidaemia by Gram positive cell wall components

The paper transplants mouse high fat diet microbiota into zebrafish larvae to identify microbial factors that accelerate hyperlipidaemia via MyD88 signaling.

Glucose inhibits haemostasis and accelerates diet-induced hyperlipidaemia in zebrafish larvae

This study shows glucose impairs haemostasis and promotes hyperlipidaemia in zebrafish larvae, with distinct effects from mammals.

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

Multiple spatial behaviours govern social network positions in a wild ungulate

The paper uses a 43-year dataset of red deer to show how spatial behaviors and other factors shape social network positions.

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques

This study shows that the ChAdOx1 nCoV-19 vaccine reduces SARS-CoV-2 viral load and prevents pneumonia in rhesus macaques without causing immune-enhanced disease.

Fitness costs of parasites explain multiple life history tradeoffs in a wild mammal

The paper examines how parasite burdens mediate reproductive and fitness tradeoffs in red deer, showing increased parasite counts during lactation correlate with reduced survival and fecundity in the following year.

Reproduction has different costs for immunity and parasitism in a wild mammal

This study examines the relationship between reproduction, immunity, and parasitism in wild female red deer, finding that gestation reduces IgA but not parasitism, while lactation increases parasitism despite no immune cost.