Author

L. Mendonca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:microscopy & imaging analysis· 3 Research Focus:protein structure prediction· 2 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

P. Zhang· 4 shared A. Howe· 3 shared A.-S. Krebs· 3 shared D. Sun· 2 shared J. Radecke· 2 shared S. Morris· 2 shared T. Lambe· 2 shared T. Ni· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersMicrobiology

P. Zhang

Mutual co-authors in cluster

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5 papers

Recent·Most cited

ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

P. Zhang, S. Gilbert, J. Radecke, T. Ni, L. Mendonca, Y. Zhu, A. Howe, P. M. Shah, Y. Sheng, A.-S. Krebs, H. M. E. Duyvesteyn, E. Allen, T. Lambe, C. Bissett, S. Morris, , D. I. Stuart

This study determines the native structure of ChAdOx1-vectored SARS-CoV-2 vaccines on cell surfaces, showing prefusion spikes in one-RBD-up conformation and improved RBD exposure in HexaPro-stabilized variants.

bioRxiv · May 22, 2023Microbiology

HIV-2 Immature Particle Morphology Provides Insights into Gag Lattice Stability and Virus Maturation

N. Talledge, H. Yang, K. Shi, R. Coray, G. Yu, W. G. Arndt, S. Meng, G. C. Baxter, L. Mendonca, D. Castano-Dlez, H. Aihara, L. M. Mansky, W. Zhang

This study determines the 3D structure of HIV-2 immature Gag lattice using cryo-EM and identifies structural features critical for particle release and infectivity.

bioRxiv · Feb 1, 2022Microbiology

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

Y. Watanabe, L. Mendonca, E. R. Allen, A. Howe, M. Lee, J. D. Allen, H. Chawla, D. Pulido, F. Donnellan, H. Davies, M. Ulaszewska, S. Belij-Rammerstorfer, S. Morris, A.-S. Krebs, W. Dejnirattisai, , M. Crispin

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

bioRxiv · Jan 15, 2021Microbiology

SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-modal Multi-scale Cryo-imaging

L. Mendonca, A. Howe, J. B. Gilchrist, D. Sun, M. Knight, L. C. Zanetti-Domingues, B. Bateman, A.-S. Krebs, L. Chen, J. Radecke, Y. Sheng, V. D. Li, T. Ni, I. Kounatidis, M. A. Koronfel, , P. Zhang

This study uses cryo-imaging to reveal SARS-CoV-2 replication, assembly, and egress pathways in infected cells.

bioRxiv · Nov 5, 2020 · PreprintMicrobiology

CryoET structures of immature HIV Gag reveal a complete six-helix bundle and stabilizing small molecules distinct from IP6

L. Mendonca, D. Sun, J. Ning, J. Liu, A. Kotecha, M. Olek, T. Frosio, X. Fu, B. A. Himes, A. B. Kleinpeter, E. O. Freed, J. Zhou, C. Aiken, P. Zhang

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.

bioRxiv · Oct 31, 2020 · PreprintMicrobiology