Salmonella Typhimurium employ spermidine to exert protection against ROS-mediated cytotoxicity and rewires host polyamine metabolism to ameliorate its survival in macrophages
A. V. Nair, A. Singh, R. S. Rajmani, D. Chakravortty
This study shows Salmonella Typhimurium uses spermidine to resist ROS stress and rewires host polyamine metabolism, enhancing survival in macrophages, and suggests DFMO as a therapeutic option.