Author

M. D. Hogarty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 8

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:proteomics· 3

Frequent Co-Authors

A. Vu· 3 shared F. Speleman· 2 shared J. Skoda· 2 shared K. Liu· 2 shared Y. Li· 2 shared A. C. Resnick· 1 shared A. Decock· 1 shared A. J. Waanders· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersCancer Biology

A. Vu

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8 papers

Recent·Most cited

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

S. Cherkaoui, L. Yang, M. J. McBride, C. Turn, W. Lu, C. Eigenmann, G. E. Allen, O. O. Panasenko, L. Zhang, A. Vu, K. Liu, Y. Li, O. H. Gandhi, L. Surrey, M. Wierer, , R. J. Morscher

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

bioRxiv · Jan 7, 2024Cancer Biology

Inhibiting mitochondrial translation overcomes multidrug resistance in MYC-driven neuroblastoma via OMA1-mediated integrated stress response

K. Borankova, M. Krchniakova, L. Y. Leck, J. Neradil, A. Kubistova, P. J. Jansson, M. D. Hogarty, J. Skoda

bioRxiv · Feb 24, 2023Cancer Biology

Anti-GD2 antibody therapy alters the neuroblastoma tumor microenvironment and extends survival in TH-MYCN mice

K. O. McNerney, S. Karageorgos, G. Ferry, A. Wolpaw, C. Burudpakdee, P. Khurana, R. Vemu, A. Vu, M. D. Hogarty, H. Bassiri

bioRxiv · Jun 9, 2021 · PreprintCancer Biology

REDUCED ER-MITOCHONDRIA CONNECTIVITY PROMOTES NEUROBLASTOMA MULTIDRUG RESISTANCE

J. Coku, D. M. Booth, J. Skoda, M. C. Pedrotty, J. Vogel, K. Liu, A. Vu, E. L. Carpenter, J. C. Ye, M. A. Chen, P. Dunbar, E. Scadden, E. Nakamaru-Ogiso, Y. Li, K. C. Goldsmith, , M. D. Hogarty

The paper identifies reduced ER-mitochondria contacts as a mechanism promoting neuroblastoma multidrug resistance by impairing Ca2+ transfer and apoptosis.

bioRxiv · Mar 1, 2021Cancer Biology

Epigenetic state determines inflammatory sensing in neuroblastoma

A. J. Wolpaw, L. D. Grossmann, M. M. Dong, J. L. Dessau, P. A. Brafford, D. Volgina, A. Rodriguez-Garcia, Y. Uzun, D. J. Powell, K. Tan, M. D. Hogarty, J. M. Maris, C. V. Dang

The paper shows that epigenetic states in neuroblastoma cells determine their response to inflammatory stimuli, with mesenchymal states being more responsive than adrenergic states.

bioRxiv · Jan 27, 2021Cancer Biology

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

S. Zanotti, S. Vanhauwaert, C. Van Neste, V. Olexiouk, J. Van Laere, M. Verschuuren, L. M. Mus, K. Durinck, L. Tilleman, D. Deforce, F. Van Nieuwerburgh, M. D. Hogarty, B. Decaesteker, W. H. De Vos, F. Speleman

This study shows that MYCN activation in RPE cells causes nucleolar stress and a senescence-like transcriptional program without full senescence hallmarks, leading to growth attenuation.

bioRxiv · Jan 22, 2021Cancer Biology

Novel BRAF gene fusions in pediatric histiocytic neoplasms define distinct therapeutic responsiveness to RAF paradox breakers

P. Jain, L. F. Surrey, J. Straka, P. Russo, R. Womer, M. Li, P. B. Storm, A. J. Waanders, M. D. Hogarty, A. C. Resnick, J. Picarsic

The paper identifies two novel BRAF gene fusions in pediatric histiocytic neoplasms and shows they respond differently to RAF inhibitor therapies due to distinct dimerization mechanisms.

bioRxiv · Apr 13, 2020Cancer Biology

Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients

F. Zeka, A. Van Goethem, K. Vanderheyden, F. Demuynck, T. Lammens, A. Decock, H. H. Helsmoortel, J. Vermeulen, R. Noguera, A. P. Berbegall, V. Combaret, G. Schleiermacher, G. Laureys, A. Schramm, J. H. Schulte, , J. Vandesompele

This study identifies 9 miRNAs associated with metastatic neuroblastoma by analyzing serum miRNome in patient cohorts and xenografted mice.

bioRxiv · Apr 27, 2018Cancer Biology