Z. H. Zhou

This study identifies the epoxidase enzyme responsible for converting strictosamide to its epoxide form using a chemoproteomic approach in Ophiorrhiza pumila.

The study identifies a suppressor mutation in HSV-1 NEC that stabilizes the hexagonal lattice, restoring membrane budding in various mutants.

This study uses cryoEM to reveal the oligomeric isomers and assembly mechanics of PCC from Leishmania tarentolae, showing how subunit attachment affects enzymatic activity.

This study identifies FAP106 as a critical interaction hub for assembling conserved and lineage-specific microtubule inner proteins at the cilium inner junction in Trypanosoma brucei.

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of human red blood cell membranes and their protein distribution.

This paper introduces IsoNet, a deep learning tool that reduces resolution anisotropy in cryoET data, improving structural interpretability without sub-tomogram averaging.

This study determines the structure of TRPV2 bound to cannabidiol, revealing a unique binding site and the role of the S4-S5 linker in channel gating.

The paper determines TRPV5 structures with endogenous modulators PI(4,5)P2 and CaM, revealing their mechanisms of activation and inhibition.

This paper introduces DRRAFTER, a method to model RNA-protein complexes from cryoEM maps, showing it can build accurate RNA coordinates in real-world scenarios.