A. Wells

APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranes

The paper shows APP and Aβ-peptides modulate protein aggregation and DCG biogenesis in Drosophila cells, with mutant Aβ-peptides disrupting these processes and causing AD-like pathologies.

A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells

The paper studies DCG biogenesis in Drosophila secondary cells, identifying a Rab6 to Rab11 transition essential for DCG and exosome formation.

A CXCR3-activating peptide increases Tear Break Up Time and corrects corneal haze in a rabbit model of environmental dry eye

A CXCR3-activating peptide improves tear quality and reduces corneal haze in a rabbit model of environmental dry eye without affecting tear volume.

Axl contributes to efficient migration and invasion of melanoma cells

This study investigates Axl's role in melanoma cell migration and invasion, finding that Axl inhibition reduces these processes in vitro.

Interferon-γ Increases Sensitivity to Chemotherapy and Provides Immunotherapy Targets in Models of Metastatic Castration-Resistant Prostate Cancer

Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice

This study shows that hFcRn and IFN signaling determine echovirus pathogenesis in mice, with hFcRn-IFNAR-/- mice modeling human disease.

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients

The paper investigates SARS-CoV-2 growth, furin-cleavage-site adaptation, and neutralization using serum from hospitalized COVID-19 patients, finding neutralizing antibody titers are comparable regardless of furin cleavage signal integrity.

Type III interferon signaling restricts Enterovirus 71 infection of goblet cells

This study shows EV71 infects goblet cells in the human intestinal epithelium and that type III IFNs restrict its replication.

Skew in ovarian activation depends on domicile size in a facultatively social thrips

The paper shows that in facultatively social thrips, reproductive skew and breeding success depend on domicile size and social structure.