APP and β-amyloid modulate protein aggregation and dissociation from recycling endosomal and exosomal membranes
P. J. Singh, B. Verma, A. Wells, C. C. Mendes, D. Dunn, Y.-N. Chen, J. Oh, L. Blincowe, M. Wainwright, R. Fischer, S.-J. Fan, A. L. Harris, D. C. Goberdhan, C. Wilson
The paper shows APP and Aβ-peptides modulate protein aggregation and DCG biogenesis in Drosophila cells, with mutant Aβ-peptides disrupting these processes and causing AD-like pathologies.
bioRxiv · Mar 28, 2024 · PreprintCell Biology