Author

A. Herbert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

D. M. Towers· 2 shared G. C. Ippolito· 2 shared J. D. Gollihar· 2 shared J. Dye· 2 shared K. Chandran· 2 shared K.-L. Chan· 2 shared T. Olukoga· 2 shared A. Agrawal· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

D. M. Towers

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Author profile →

8 papers

Recent·Most cited

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

M. Fernandez-Casanas, E. Karanika, T. Olukoga, A. Herbert, U. Aliyaskarova, M. Day, K.-L. Chan

This study identifies a centromere protection pathway in human mitotic cells that relies on strict mitotic inactivation of the BTRR complex through phosphorylation and kinase regulation.

bioRxiv · May 21, 2024Cell Biology

Engineering, structure, and immunogenicity of a Crimean-Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex

E. McFadden, S. Monticelli, A. Wang, A. Ramamohan, T. Batchelor, A. Kuehne, R. Bakken, A. Tse, K. Chandran, A. Herbert, J. McLellan

The paper describes the structure and immunogenicity of a stabilized CCHFV heterotrimeric glycoprotein complex and shows it provides 40% protection against viral challenge in mice.

bioRxiv · Apr 20, 2024 · PreprintMicrobiology

Z-RNA and the flipside of the SARS Nsp13 helicase

A. Herbert, M. Poptsova

This paper identifies Z-RNA modulating activities in SARS Nsp13 and proposes mechanisms by which it suppresses Z-RNA-dependent innate immunity.

bioRxiv · Mar 3, 2022 · PreprintMicrobiology

Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes in COVID-19 convalescent plasma

W. N. Voss, Y. J. Hou, N. V. Johnson, J. E. Kim, G. Delidakis, A. P. Horton, F. Bartzoka, C. J. Paresi, Y. Tanno, S. A. Abbasi, W. Pickens, K. George, D. R. Boutz, D. M. Towers, J. R. McDaniel, , G. C. Ippolito

The paper identifies prevalent, protective, and convergent IgG antibodies targeting non-RBD epitopes of SARS-CoV-2 spike protein in convalescent plasma.

bioRxiv · Dec 20, 2020Immunology

Relationship between Anti-Spike Protein Antibody Titers and SARS-CoV-2 In Vitro Virus Neutralization in Convalescent Plasma

E. Salazar, S. V. Kuchipudi, P. A. Christensen, T. N. Eagar, X. Yi, P. Zhao, Z. Jin, S. W. Long, R. J. Olsen, J. Chen, B. Castillo, C. Leveque, D. M. Towers, J. Lavinder, J. D. Gollihar, , J. M. Musser

This study finds a strong correlation between anti-RBD and anti-ECD IgG titers and in vitro virus neutralization titers in convalescent plasma, suggesting these titers can serve as surrogates for neutralizing activity.

bioRxiv · Jun 8, 2020Immunology

PLK1 protects centromeres from BLM-mediated disintegration to promote chromosome biorientation

O. Addis Jones, A. Tiwari, T. Olukoga, A. Herbert, K.-L. Chan

This study shows PLK1 protects centromeres from BLM-mediated disintegration, which is critical for maintaining chromosome biorientation during mitosis.

bioRxiv · Dec 17, 2018Cell Biology

Super-resolution fight club: A broad assessment of 2D & 3D single-molecule localization microscopy software

D. Sage, T.-A. Pham, H. Babcock, T. Lukes, T. Pengo, J. Chao, R. Velmurugan, A. Herbert, A. Agrawal, S. Colabrese, A. Wheeler, A. Archetti, B. Rieger, R. Ober, G. M. Hagen, , S. Holden

The paper evaluates 36 single-molecule localization microscopy software packages using simulated datasets to assess their performance in 2D and 3D imaging.

bioRxiv · Dec 1, 2018Biophysics

Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody

B. R. West, A. Z. Wec, C. L. Moyer, M. L. Fusco, P. A. Illinykh, K. Huang, R. James, A. Herbert, S. Hui, A. S. Wirchnianski, E. Goodwin, M. J. Aman, L. M. Walker, J. M. Dye, A. Bukreyev, , E. O. Saphire

The paper determines the structure of a broadly neutralizing antibody against ebolavirus, identifies a conserved epitope, and explains factors affecting its activity against related viruses.

bioRxiv · Aug 19, 2018Immunology