J. Chao

The diversity of clinical Mycobacterium abscessus isolates in morphology, glycopeptidolipids and infection rates in a macrophage model

This study examines the relationship between morphology, glycopeptidolipids, and infectivity in Mycobacterium abscessus clinical isolates using macrophage models.

Highly efficient multiplex genome editing in dicot plants using improved CRISPR/Cas systems

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

The synergistic effect of circRNA methylation promotes pulmonary fibrosis

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

Single-molecule imaging reveals translation of mRNAs localized to stress granules

This study uses single-molecule imaging to show that mRNAs localized to stress granules are translated, challenging the assumption that SGs exclusively contain nontranslating mRNA.

Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition

The paper designs a DNA nanostructure that recognizes and inhibits dengue virus through precise spatial arrangement of aptamers, enabling sensitive and rapid sensing and inhibition.

Super-resolution fight club: A broad assessment of 2D & 3D single-molecule localization microscopy software

The paper evaluates 36 single-molecule localization microscopy software packages using simulated datasets to assess their performance in 2D and 3D imaging.

Intensity-based axial localization approaches for multifocal plane microscopy

This paper evaluates intensity-based axial localization methods for multifocal plane microscopy and introduces a new non-parametric method, MILA, which improves robustness against sub-pixel location biases.