A. Yates

A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in mice

This study maps the ontogeny of Treg subsets in mice, showing naive and effector/memory Treg are continuously replenished by de novo generation, with naive Treg being the main precursor of EM Treg in adults.

Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa

The paper identifies tertiary lymphoid structures in HS lesions and shows B cell maturation and interactions with T cells and stroma.

Notch2 signaling guides B cells away from germinal centers towards marginal zone B cell and plasma cell differentiation

The paper shows Notch2 signaling drives B cells from germinal centers to become marginal zone B cells or plasma cells, with mathematical modeling supporting this pathway.

Towards a unified model of naive T cell dynamics across the lifespan

This study develops a unified model of naive CD4 and CD8 T cell dynamics across the mouse lifespan, revealing that survival capacity increases with age and that naive CD8 T cells are rapidly lost early in life.

Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

This study investigates how self and environmental antigens influence the development and maintenance of CD4+ T cell memory in mice, showing early environmental exposure shapes memory populations, while later replenishment is environment-independent.

Cell Generation Dynamics Underlying Naïve T Cell Homeostasis in Adult Humans

This study measures age-related changes in naive T cell turnover using 14C dating and identifies NF-κB signaling as critical for homeostatic proliferation.