H. Harris

Pharmacological inhibition of macrophage triglyceride biosynthesis pathways does not improve Mycobacterium tuberculosis control in infected mice

This study evaluates two compounds that reduce triglyceride content in Mtb-infected macrophages but finds they do not reduce bacterial burden or inflammation in infected mice.

Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand

This study characterizes bovine Mincle, showing structural and functional similarity to human Mincle, with potential endogenous ligand recognition.

Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa

The paper identifies tertiary lymphoid structures in HS lesions and shows B cell maturation and interactions with T cells and stroma.

Linking carbohydrate structure with function in the human gut microbiome using hybrid metagenome assemblies

This study uses hybrid metagenome assemblies to analyze how structurally distinct carbohydrates affect gut microbiome composition and function by identifying carbohydrate-degrading microbes and their enzymatic capabilities.

Pilot study: Trehalose-induced remodelling of the human microbiota affects Clostridioides difficile infection outcome in an in vitro colonic model

This study shows that trehalose supplementation remodels the human gut microbiota, preventing simulated Clostridioides difficile infection in an in vitro model.

Bovine neutrophils release extracellular traps and cooperate with macrophages in Mycobacterium avium subsp. paratuberculosis clearance in vitro

This study investigates how bovine neutrophils and macrophages interact to clear Mycobacterium avium subsp. paratuberculosis in vitro, showing synergistic effects and reduced inflammation.