B. Hao

Nematode Extracellular Protein Interactome Expands Connections between Signaling Pathways

The paper reports a C. elegans extracellular interactome dataset, revealing new interactions between signaling pathways and potential roles in human disease mechanisms.

TRACTION FORCE AND MECHANOSENSING CAN BE FUNCTIONALLY DISTINGUISHED THROUGH THE USE OF SPECIFIC DOMAINS OF THE CALPAIN SMALL SUBUNIT

This study identifies that specific domains of Calpain 4 regulate either traction force or mechanosensing independently.

Regulation of Traction Force through the Direct Binding of Basigin and Calpain 4

This study identifies basigin as a binding partner of calpain 4, showing it regulates traction force without requiring the catalytic subunits.

A Real-Time Analysis of Protein Transport via the Twin Arginine Translocation Pathway in Response to Different Components of the Protonmotive Force in vivo

This study develops a real-time assay to analyze the energy requirements of the Tat pathway in E. coli, showing that both ΔpH and Δψ contribute to protein transport in vivo.

Within-host genotypic and phenotypic diversity of contemporaneous carbapenem-resistant Klebsiella pneumoniae from blood cultures of patients with bacteremia

The paper identifies genotypic and phenotypic diversity among CRKP strains from individual patients' blood cultures, showing they are genetically distinct and exhibit different antibiotic responses and virulence traits.

Functional analysis of the polar amino acid in TatA transmembrane helix

The paper examines the functional role of a polar amino acid in the TatA transmembrane helix of Escherichia coli, finding that while preferred, it is not essential for Tat activity, with hydrophobicity and charge affecting transport efficiency.

Hydrophobic mismatch is a key factor in protein transport on the Tat pathway

This study modifies the transmembrane helix lengths of TatA and TatB in E. coli to assess the role of hydrophobic mismatch in Tat pathway function, finding that 15 residues are optimal for membrane integrity and transport activity.

Contrasting biogeographic patterns of bacterial and archaeal diversity in the top- and subsoils of temperate grasslands

This study compares microbial diversity patterns in top- and subsoils of temperate grasslands along an aridity gradient, finding contrasting diversity trends and drivers between soil depths.