T. Chu

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut

This study identifies distinct roles for crypt and villus enterochromaffin cells in sensing gut irritants and oxidative stress through different TRP channels and signaling mechanisms.

Vessel normalization and maturation promotes nanoparticle delivery to solid tumors while minimizing metastases.

This study shows that vessel normalization improves nanoparticle delivery to solid tumors and reduces metastases, but its effectiveness depends on nanoparticle size and tumor characteristics.

Within-host genotypic and phenotypic diversity of contemporaneous carbapenem-resistant Klebsiella pneumoniae from blood cultures of patients with bacteremia

The paper identifies genotypic and phenotypic diversity among CRKP strains from individual patients' blood cultures, showing they are genetically distinct and exhibit different antibiotic responses and virulence traits.

A lymphatic-stem cell interactome regulates intestinal stem cell activity

The paper identifies lymphatic-secreted factors that maintain intestinal stem cells and inhibit their premature differentiation through a novel deconvolution algorithm and spatial transcriptomics.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

Selectively increased autofluorescence at certain regions of skin may become a novel diagnostic biomarker for lung cancer

This study shows increased epidermal green autofluorescence in skin and nails of lung cancer patients and mice, suggesting it as a potential non-invasive diagnostic biomarker.

Minutes-timescale 3D isotropic imaging of entire organs at subcellular resolution by content-aware compressed-sensing light-sheet microscopy

This paper introduces a computational light-sheet microscopy method that rapidly images entire organs at subcellular resolution, achieving high isotropic spatial resolution and significantly improved throughput.

Identification of Relevant Genetic Alterations in Cancer using Topological Data Analysis

This study identifies 38 candidate cancer-associated genes using topological data analysis integrated with somatic mutations and RNA expression data across 12 tumor types.

Transcriptome analysis of the Larimichthys polyactis under heat and cold stress

This study identifies differentially expressed genes and pathways in small yellow croaker liver under heat and cold stress, providing insights into temperature stress responses for aquaculture improvement.