Author

B. Ozbek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:spatial transcriptomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. M. De Marzo· 4 shared E. S. Antonarakis· 2 shared J. Chen· 2 shared J. L. Hicks· 2 shared Q. Zheng· 2 shared S. Yegnasubramanian· 2 shared T. Jones· 2 shared A. Gupta· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCancer Biology

A. M. De Marzo

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4 papers

Recent·Most cited

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

J. Chen, Q. Zheng, J. L. Hicks, L. Trabzonlu, B. Ozbek, T. Jones, A. Vaghasia, T. C. Larman, R. Wang, M. C. Markowski, S. R. Denmeade, K. J. Pienta, R. H. Hruban, E. S. Antonarakis, A. Gupta, , A. M. De Marzo

The paper develops a method to spatially quantify mitochondrial DNA copy number in cancer tissues and finds increased mtDNAcn in prostate cancer progression, linked to MYC activity.

bioRxiv · Feb 20, 2023Cancer Biology

Supraphysiological testosterone induces ferroptosis and activates NF-kappaB mediated immune pathways in prostate cancer through nucleophagy

J. Mendonca, R. Kumar, O. Owoyemi, K. Boyapati, N. Thomas, S. Kanacharoen, M. Coffey, D. Topiwala, C. Gomes, B. Ozbek, T. Jones, M. Rosen, L. Dong, S. Wiens, W. N. Brennen, , S. Kachhap

bioRxiv · Sep 10, 2020 · PreprintCancer Biology

Oncogenic gene fusions in non-neoplastic precursors as evidence that bacterial infection initiates prostate cancer

E. Shrestha, J. Coulter, W. Guzman, B. Ozbek, L. Mummert, S. Ernst, J. Maynard, A. Meeker, C. Heaphy, M. Haffner, A. M. De Marzo, K. S. Sfanos

This study shows bacterial infections initiate prostate cancer by causing DNA breaks that lead to oncogenic TMPRSS2:ERG fusions in precancerous lesions like PIA.

bioRxiv · Jul 27, 2020Cancer Biology

An in situ atlas of mitochondrial DNA in mammalian tissues reveals high content in stem/progenitor cells

J. Chen, Q. Zheng, L. B. Peiffer, J. L. Hicks, M. C. Haffner, A. Z. Rosenberg, M. Levi, X. X. Wang, B. Ozbek, S. Yegnasubramanian, A. M. De Marzo

The paper creates an in situ atlas of mitochondrial DNA in mammalian tissues, revealing higher mtDNA content in stem/progenitor cells and age-related decreases in renal tubules.

bioRxiv · Dec 19, 2019Pathology