N. Thomas

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor.

This study shows CRM1 regulates androgen receptor stability and DNA repair in prostate cancer, suggesting combination therapy with CRM1 and DNA repair inhibitors could be effective.

Mapping chromatin state and transcriptional response in CIC-DUX4 undifferentiated round cell sarcoma

This study identifies CIC-DUX4-mediated chromatin states and transcriptional responses in sarcoma using ChIP and RNA-Seq analysis of patient-derived cells.

Computational design of N-linked glycans for high throughput epitope profiling

The paper develops a computational method using N-linked glycans to rapidly map epitopes, validated through ELISA, yeast display, and X-ray crystallography using human coagulation factor IXa.

Multi-scale observations of mangrove blue carbon fluxes; the NASA Carbon Monitoring System BlueFlux field campaign

The paper describes the BlueFlux field campaign, which measures CO2 and CH4 fluxes in mangroves using multiple methods and scales them to gridded products to improve climate change mitigation strategies.

Attenuation of a DNA Cruciform by a Conserved Regulator Directs T3SS-1 mediated virulence in Vibrio parahaemolyticus

This study shows HlyU attenuates a DNA cruciform to enable T3SS-1 virulence gene expression in Vibrio parahaemolyticus by activating an ExsA autoactivation loop.

Shared and distinct genetic features in human and canine B-cell lymphomas

This study compares genetic mutations in canine and human B-cell lymphomas, identifying shared and distinct features that may affect their biology and therapeutic development.

Non-coding NFKBIZ 3' UTR mutations promote cell growth and resistance to targeted therapies in diffuse large B-cell lymphoma

This study identifies non-coding NFKBIZ 3' UTR mutations as drivers of DLBCL growth and resistance to NF-κB-targeted therapies, suggesting their potential as biomarkers.

Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

Direct Nanopore Sequencing of Individual Full Length tRNA Strands

This paper describes a method for direct tRNA sequencing using Oxford Nanopore MinION, achieving 76-92% full-length reads and detecting all 42 tRNA isoacceptors in E. coli.

Phospholipids stabilize binding of pituitary adenylate cyclase-activating peptide to vasoactive intestinal polypeptide receptor

The paper shows phospholipids stabilize PACAP27 binding to VIP1R by lowering binding free energy through specific lipid interactions.

Lateral electric field inhibits gel-to-fluid transition in lipid bilayers

The paper shows lateral electric fields increase the melting temperature of lipid bilayers in simulations, suggesting new insights into lipid interactions under electric fields.

Quantification of in-plane flexoelectricity in lipid bilayers

The paper quantifies in-plane flexoelectricity in lipid bilayers using molecular dynamics simulations and computes an effective in-plane flexoelectric coefficient for four lipid types.

Supraphysiological testosterone induces ferroptosis and activates NF-kappaB mediated immune pathways in prostate cancer through nucleophagy

Electromechanics of lipid-modulated gating of Kv channels

The paper investigates how anionic lipids and cholesterol modulate Kv channel gating through electrostatic and mechanical interactions, showing lipid-specific effects on channel activity.

Comparison of vibrotactile and joint-torque feedback in a myoelectric upper-limb prosthesis

This study compares vibrotactile and joint-torque feedback in a myoelectric prosthesis, finding that both improve object discrimination accuracy, though no significant difference exists between the two modalities.