A. B. Smith

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity

This paper combines three CD4-induced antibodies with a CD4-mimetic to achieve potent ADCC activity against HIV-1-infected cells.

Pervasive but lagged responses in the composition of small mammal communities to a century of climate change

The paper analyzes long-term small mammal community responses to climate change across three regions in California, finding that community composition lags behind climate change rates.

V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins

This study identifies residue changes in the gp120 V3 loop that influence susceptibility of HIV-1 Envs to CD4-mimetic compounds, showing how variations outside the binding site affect inhibitor sensitivity.

Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC

The paper describes piperidine-based CD4-mimetic compounds that expose HIV-1 Env epitopes, increasing sensitivity to ADCC by targeting Asp368.

Conformations of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles (SMALPs)

This study compares the stability and conformation of HIV-1 Env in detergents versus SMA lipids, showing SMA preserves the pretriggered state better at room temperature.

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity

The paper shows that small CD4 mimetics expose ADCC epitopes on HIV-1-infected macrophages, making them susceptible to antibody-dependent cellular cytotoxicity.

Modeling the rarest of the rare: A comparison between joint species distribution models, ensembles of small models, and single-species models at extremely low sample sizes

This study compares modeling approaches for rare species at low sample sizes, finding that ensembles of small models perform better in discrimination tasks, while joint species models better estimate niche responses.

Dynamics of mRNA fate during light stress and recovery: from transcription to stability and translation

The paper investigates how mRNA stability, transcription, and translation change during light stress and recovery in Arabidopsis thaliana, finding transcript destabilisation during stress and stabilisation during recovery.

Characterization of human immunodeficiency virus (HIV-1) envelope glycoprotein variants selected for resistance to a CD4-mimetic compound

This study identifies HIV-1 Env variants resistant to CD4-mimetic compounds and BMS-806 by analyzing mutations that confer resistance and their effects on viral fitness and inhibitor sensitivity.

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

This study shows that HIV-1 Vpu reduces nnAb recognition and ADCC resistance, with nnAb Fc-effector functions dependent on Env's open conformation.

VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

Global Increases in Human Immunodeficiency Virus Neutralization Sensitivity Due to Alterations in the Membrane-Proximal External Region of the Envelope Glycoprotein Can be Minimized by Distant State 1-Stabilizing Changes

The paper shows that changes in the MPER of HIV-1 Env lead to premature triggering and increased neutralization sensitivity, which can be counteracted by distant State 1-stabilizing Env modifications.

HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC mediated by plasma from infected individuals

This study shows that HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC by reducing the exposure of uncleaved Env to non-neutralizing antibodies.

Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice

AdipoRon, an adiponectin receptor agonist, improves skeletal muscle function in aged mice by enhancing mitochondrial activity and metabolism, with effects observed in both mice and nonhuman primates.

Including imprecisely georeferenced specimens improves accuracy of species distribution models and estimates of niche breadth

The paper improves species distribution models by including imprecisely georeferenced specimens, showing better accuracy and niche breadth estimates compared to using only precise records.

Retrograde Control of Cytosolic Translation Targets Synthesis of Plastid Localized Proteins and Nuclear Responses for Efficient Light Acclimation.

The paper identifies a translation-dependent retrograde signaling pathway that regulates chloroplast protein synthesis and nuclear responses to light acclimation.

Occupancy-collection models: Towards bias-corrected modeling of species' distributions using unstructured occurrence data from museums and herbaria

This study adapts occupancy-detection models to correct biases in opportunistic species occurrence data from museums and citizen science, using Anacardiaceae in Florida as a case study.

Cryo-EM Structures of HIV-1 trimer bound to CD4-mimetics M48U1 and BNM-III-170 adopt a CD4-bound open conformation

The paper presents cryo-EM structures of HIV-1 Env trimers bound to CD4-mimetics, showing conformational changes induced by Phe43 pocket binding.

Testing the ability of species distribution models to infer variable importance

This study evaluates how well species distribution models can identify and quantify the importance of environmental variables using simulations and permutation tests.