Author

C. Abrams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Finzi· 4 shared A. B. Smith· 3 shared J. Richard· 3 shared M. Pazgier· 3 shared S. Ding· 3 shared C. Bourassa· 2 shared D. Yang· 2 shared H. Medjahed· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersMicrobiology

A. Finzi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Temperature-dependent Spike-ACE2 interaction of Omicron subvariants is associated with viral transmission

M. Benlarbi, S. Ding, E. Belanger, A. Tauzin, R. Poujol, H. Medjahed, O. El Ferri, Y. Bo, C. Bourassa, J. Hussin, J. Fafard, M. Pazgier, I. Levade, C. Abrams, M. Cote, A. Finzi

This study examines how temperature affects Spike-ACE2 interactions in Omicron subvariants and links these interactions to viral transmission efficiency.

bioRxiv · Jan 20, 2024Microbiology

Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC

S. Ding, W. D. Tolbert, H. Zhu, D. Lee, T. Higgins, X. Zhao, D. Nguyen, R. Sherburn, J. Richard, G. Gendron-Lepage, H. Medjahed, M. Mohammadi, C. Abrams, M. Pazgier, A. B. Smith, A. Finzi

The paper describes piperidine-based CD4-mimetic compounds that expose HIV-1 Env epitopes, increasing sensitivity to ADCC by targeting Asp368.

bioRxiv · Mar 23, 2023 · PreprintImmunology

Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity

C. J. Fritschi, S. Anang, Z. Gong, M. Mohammadi, J. Richard, C. Bourassa, K. T. Severino, H. Richter, D. Yang, H.-C. Chen, T.-J. Chiu, M. Seaman, N. Madani, C. Abrams, A. Finzi, , A. B. Smith

This study designs and evaluates indoline-based CD4-mimetic compounds that inhibit HIV-1 more potently and broadly than existing indane-based compounds and sensitize HIV-1 to antibody-dependent cellular cytotoxicity.

bioRxiv · Jan 2, 2023 · PreprintMicrobiology

Molecular Dynamics Simulations of Ion Permeation in human NaV Channels

G. Alberini, S. A. Paz, B. Corradi, C. Abrams, F. Benfenati, L. Maragliano

This paper uses molecular dynamics simulations to study ion permeation mechanisms in human Nav channels, revealing distinct single and double Na+ translocation pathways in the selectivity filter.

bioRxiv · Sep 29, 2022Biophysics

VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry

S. Ding, S. Y. Gong, J. Grover, M. Mohammadjavad, Y. Chen, D. Vezina, G. Beaudoin-Bussieres, V. T. Verma, G. Goyette, J. Richard, D. Yang, A. B. Smith, M. Pazgier, M. Cote, C. Abrams, , C. Baron

VE607 inhibits SARS-CoV-2 infection by stabilizing the RBD in the 'up' conformation and blocking S-ACE2 interaction across multiple variants.

bioRxiv · Feb 3, 2022Microbiology