C. Chow

Muscle-restricted Nox4 knockout partially corrects muscle contractility following spinal cord injury in mice

This study shows that muscle-specific Nox4 knockout in mice improves muscle contractility after spinal cord injury, though force remains lower than in uninjured controls.

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.

Arginine depletion through ADI-PEG20 to treat argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type

This paper identifies ASS1 deficiency in rare ovarian cancers and shows that ADI-PEG20 inhibits tumor growth in ASS1-deficient models.